| XRCC1基因多态性与乳腺癌遗传易感性的Meta分析 |
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| 引用本文： | 芮瑞,刘莉,段生宇,钟荣,刘丽,聂绍发,缪小平,袁芃. XRCC1基因多态性与乳腺癌遗传易感性的Meta分析[J]. 中国优生与遗传杂志, 2011, 0(9): 7-11,20 |
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| 作者姓名： | 芮瑞 刘莉 段生宇 钟荣 刘丽 聂绍发 缪小平 袁芃 |
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| 作者单位： | 华中科技大学公共卫生学院;中国医学科学院肿瘤医院内科; |
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| 摘 要： | 目的综合评估XRCC1（X-Ray Repair Cross Complementing Protein 1,XRCC1）基因单核苷酸多态性与乳腺癌易感性的关系。方法以＂Breast cancer＂、＂Polymorphism＂、＂XRCC1＂、＂Arg399Gln＂、＂Arg194Trp＂、＂Arg280His＂以及＂-77T〉C＂等为主题词检索Pubmed等英文数据库,同时以＂乳腺癌＂及＂基因多态性＂等为主题词检索中文数据库,利用Stata10.0软件进行Meta分析。结果 XRCC1 Arg399Gln显著增加患乳腺癌风险,其纯合遗传模型（Gln/Gln vsArg/Arg）与隐性遗传模型Gln/Gln vs（Gln/Arg＋Arg/Arg）的相对危险度（Odds Ratio,OR）分别为1.12（95%CI=1.02-1.22）及1.12（95%CI=1.03-1.22）。此外,XRCC1-77T〉C亦显著增加了患乳腺癌风险,其纯合遗传模型C/C vs T/T与隐性遗传模型C/C vs（T/C＋T/T）的OR值分别为1.47（95%CI=1.00-2.17）及1.52（95%CI=1.06-2.18）。结论 XRCC1基因Arg399Gln位点Gln/Gln突变型以及-77T〉C位点C/C突变型均与乳腺癌发生相关。
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| 关 键 词： | XRCC1 基因多态 乳腺癌 Meta分析 易感性 |
Relationship between XRCC1 polymorphism and risk of breast cancer: a Meta-analysis. |
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| RUI Rui,LIU Li,DUAN Sheng-yu,ZHONG Rong,NIE Shao-fa,MIAO Xiao-ping,YUAN Peng.. Relationship between XRCC1 polymorphism and risk of breast cancer: a Meta-analysis.[J]. Chinese Journal of Birth Health & Heredity, 2011, 0(9): 7-11,20 |
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| Authors: | RUI Rui LIU Li DUAN Sheng-yu ZHONG Rong NIE Shao-fa MIAO Xiao-ping YUAN Peng. |
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| Affiliation: | RUI Rui1,LIU Li1,DUAN Sheng-yu1,ZHONG Rong1,NIE Shao-fa1,MIAO Xiao-ping1,YUAN Peng2.(1.Department of Public Health Tongji Medical College,Huazhong University of Science and Technology,Hubei 430030,China,2.Department of Cancer Hospital Chinese Academy of Medical Sciences,Beijing,100021,China) |
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| Abstract: | Objective:To determine whether XRCC1 Polymorphisms contribute to genetic susceptibility to breast cancer.Methods:Pubmed and some other databases were searched for literatures.Articles were identified by using the Medical Subject Headings term 'XRCC1','polymorphism','Arg399Gln','Arg194Trp','Arg280His','-77T>C','SNPs' and 'Breast cancer'.The Stata software package10.0 was used for meta-analysis.Results: The XRCC1 Arg399Gln significantly increased breast cancer risk,with an odds ratio(OR) of 1.12(95%CI=1.02-1.... |
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| Keywords: | XRCC1 Genetic polymorphism Breast cancer Meta-analysis Susceptibility |
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