促排后行未成熟卵泡穿刺术治疗多囊卵巢综合征的效果观察

目的观察促排卵后超声下行未成熟卵泡穿刺术（IMFP）治疗多囊卵巢综合征（PCOS）的效果。方法选择多囊卵巢综合征患者共86人，分2组。观察组43例，穿刺前用少量人类尿促性腺激素（HMG）促排卵；对照组43例，穿刺前未用HMG。在超声引导下行未成熟卵泡抽吸术，尽可能将能看到的卵泡全部抽吸干净，连续2—3个周期，穿刺后检查患者的内分泌和卵巢基础窦卵泡计数，直至达到基础窦卵泡计数≤10个／卵巢，并随访6个月记录其妊娠情况。结果两组患者窦卵泡计数、LH、LH／FSH、T值均较术前降低；卵巢过度刺激综合征发生率降低而妊娠率升高，其中观察组效果优于对照组（P〈0．01）。结论超声引导下IMFP可在一定时间内有效改善PCOS患者的内分泌状态，明显减少卵巢内窦卵泡计数，使其在以后的促排卵周期中OHSS发生率降低，排卵率及妊娠率提高，是治疗重度PCOS的一种有效途径。

To investigate the effect of the patients with polycystic ovarian syndrome treated with ultrasound-guided transvaginal immature follicle puncture after ovulation induction

Objective： To observe the treatment effect of polycystic ovarian syndrome （PCOS） by using the technique of ultrasound -guided transvaginal immature follicle puncture （IMFP） after ovulation induction . Methods ： The 86 PCOS patients were divided into 2 groups. Group Ⅰ has 43 patients of PCOS of which the ovarian hyperstimulation were controlled with HMG. Group Ⅱ has 43 patients without the treatment of HMG. IMFP was performed in all the PCOS patients. We try to puncture all the sections of the follicle as we can. On the next cycle of 2 - 3 days, the patients took the endocrine test and basic follicle number was checked by ultrasound. They underwent IMFP for 2 -3 cycles in sequence until the basic follicle number≤lO. Results： The basic follicle number, LH, LH/ FSH, T, FSH level in Group Ⅱ were higher than that of Group Ⅰ after IMFP. The AFC was decreased in the two groups. Conclusions ： IMFP can improve the abnormal endocryology, decrease the basic follicle number of the ovary. In the following COH, the rate of OHSS decreases while the rate of pregnancy increases. IMFP is a new effective way for the treatment of PCOS.