| 盐酸小檗碱对G6PD酶缺陷患者红细胞的影响 |
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| 引用本文： | 黎红平,姚英民,阳勇,李宁.盐酸小檗碱对G6PD酶缺陷患者红细胞的影响[J].中国优生与遗传杂志,2011(5):94-96,83. |
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| 作者姓名： | 黎红平 姚英民 阳勇 李宁 |
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| 作者单位： | 南方医科大学南方医院新生儿科; |
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| 摘 要： | 目的本文研究盐酸小檗碱是否会诱发红细胞G6PD酶活性缺陷患者发生溶血,为G6PD酶缺陷患者使用黄连的安全性提供参考。方法采用G6PD酶缺陷患者静脉全血,以生理盐水为空白对照,观察不同浓度盐酸小檗碱（Ber）对红细胞形态、红细胞计数（RBC）、血红蛋白（HGB）、红细胞G6PD酶活性及血浆游离血红蛋白（F-HB）的影响。结果血中Ber浓度为0.1mg/L和0.5mg/L时,红细胞形态、RBC、HGB及G6PD酶活性均无明显改变（P〉0.05）;Ber药物浓度为1mg/L时,红细胞形态有轻度改变,RBC、HGB下降（P〈0.05）,G6PD酶活性无明显变化（P〉0.05）;Ber浓度为5mg/L时,红细胞形态明显改变,RBC、HGB显著下降（P〈0.01）,红细胞G6PD酶活性显著增高（P〈0.01）;各浓度Ber溶液均可使F-HB显著下降（P〈0.01）。结论①按正常剂量使用黄连对G6PD酶缺乏者可能是安全的,大剂量Ber能使G6PD酶缺陷患者红细胞遭到损害,提示避免超剂量使用黄连。②Ber能使血浆游离血红蛋白测定值降低,可能的原因有待进一步研究分析。
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| 关 键 词： | 盐酸小檗碱 G6PD酶缺乏 人红细胞 溶血 |
Berberine hydrochloride on G6PD enzyme defects in red blood cells of patients |
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| LI Hong-ping,YAO Ying-min,YANG Yong,LI Ning..Berberine hydrochloride on G6PD enzyme defects in red blood cells of patients[J].Chinese Journal of Birth Health & Heredity,2011(5):94-96,83. |
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| Authors: | LI Hong-ping YAO Ying-min YANG Yong LI Ning |
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| Institution: | LI Hong-ping1,YAO Ying-min2,YANG Yong2,LI Ning2.(Southen Medical University of Neonatology,510515) |
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| Abstract: | Objective: This paper aims to study whether berberine can induce hemolysis for patients that have defects of G6PD activity in red blood cell,and provide a reference for patients with G6PD enzyme defects.Methods:Firstly,take whole blood from patients with G6PD defects,and then Observe the impact of different concentrations of berberine(Ber) on erythrocyte morphology,red blood cell count(RBC),hemoglobin(HGB),erythrocyte G6PD activity and plasma free hemoglobin(F-HB),at the same time,take Hydrochloric acid as ... |
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| Keywords: | Berberine G6PD enzyme deficiency Hemolysis of human Erythrocytes |
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