| 男性不育患者AZF微缺失的分子检测 |
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| 引用本文： | 慕明涛,霍满鹏,刘俊俊,张静,蒲力群.男性不育患者AZF微缺失的分子检测[J].中国优生与遗传杂志,2011(5):29-30. |
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| 作者姓名： | 慕明涛 霍满鹏 刘俊俊 张静 蒲力群 |
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| 作者单位： | 延安大学医学院医学遗传学与细胞生物学教研室遗传学研究所; |
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| 摘 要： | 目的探讨男性原发无精子症和少精子症与Y染色体无精子症因子(AZF)微缺失的关系。方法采用聚合酶链反应技术对62例原发无精子症与少精子症患者Y染色体上AZF基因(STS)上的3个位点SY84、SY127、SY254及ZFX/ZFY基因进行检测。结果 62例无精子症与少精子症患者中共检出Y染色体微缺失13例,缺失率为20.97%。其中40例无精症患者中发现9例(22.5%),22例少精症患者中发现4例(18.18%)。结论 AZF缺失是原发无精子症和少精子症造成男性不育的重要原因之一,对无精子症和少精子症患者有必要进行Y染色体微缺失的常规检测。
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| 关 键 词： | 男性不育 无精子症因子 微缺失 原发无精子症 少精子症 |
Molecular detection on relation between AZF microdeletions and male infertility |
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| MU Ming-tao,HUO Man-peng,LIU Jun-jun,ZHANG Jing,PU Li-qun..Molecular detection on relation between AZF microdeletions and male infertility[J].Chinese Journal of Birth Health & Heredity,2011(5):29-30. |
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| Authors: | MU Ming-tao HUO Man-peng LIU Jun-jun ZHANG Jing PU Li-qun |
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| Institution: | .(Institute of Genetics,Department of Medical genetics and cell biology of Medical College,Yan′an University,Yan′an 716000,Shaanxi Province,China) |
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| Abstract: | Objective:To evaluate the relationship between Y chromosome azoospermia factor(AZF) microdeletion and idiopathic azoospermia / oligospermia in males.Methods:The three sites including SY84,SY127,SY254 and ZFX/ZFY regions of Y chromosome in 62 cases of idiopathic azoospermia and oligozoospermia were detected by STS-PCR.Results: Microdeletions were detected in 20.97%(13/62) infertile men with idiopathic azoospermia or oligozoo spermia.Which 9 cases(22.5%) were found in 40 azoospermic patients and 4 cases(18.18... |
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| Keywords: | Male infertility Azoospermia factor Microdeletion Idiopathic azoospermia Oligospermia |
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