| 荧光原位杂交技术在胎儿染色体异常产前诊断中的应用 |
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| 引用本文： | 傅文婷,潘小英,尹爱华,卢健,郭莉,吴菁.荧光原位杂交技术在胎儿染色体异常产前诊断中的应用[J].中国优生与遗传杂志,2011(9):41-42,F0002. |
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| 作者姓名： | 傅文婷 潘小英 尹爱华 卢健 郭莉 吴菁 |
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| 作者单位： | 广东省妇幼保健院;广东省妇女儿童医院产前诊断中心; |
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| 摘 要： | 目的探讨荧光原位杂交(FISH)技术在检测胎儿染色体异常的临床应用。方法选用13、21、18、X、Y特异性探针对1128例孕16～22周有产前诊断指征的妊娠妇女羊水间期细胞进行分析,并与同时进行的羊水细胞培养核型分析结果进行对照。结果被检1128例羊水间期细胞FISH检测均成功,其中检出正常核型1081例,数目异常核型20例,与常规细胞染色体核型分析结果一致,另外27例结构异常FISH技术未能检出。结论 FISH技术检测胎儿染色体数目异常具有快速、简便、准确性高、特异性强等优点,有较大的临床应用价值,并对产前细胞遗传学诊断有重要意义。
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| 关 键 词： | 荧光原位杂交 产前诊断 羊水间期细胞 染色体异常 |
Clinical assessment of fluorescence in situ hybridization for prenatal diagnosis of chromosomal abnormalities. |
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| FU Wen-ting,PAN Xiao-ying,YIN Ai-hua,et al..Clinical assessment of fluorescence in situ hybridization for prenatal diagnosis of chromosomal abnormalities.[J].Chinese Journal of Birth Health & Heredity,2011(9):41-42,F0002. |
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| Authors: | FU Wen-ting PAN Xiao-ying YIN Ai-hua |
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| Institution: | FU Wen-ting,PAN Xiao-ying,YIN Ai-hua,et al.(Prenatal Diagnosis Center of GuangDong Women and Children Hospital,510010) |
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| Abstract: | Objective: To analyze the clinical application of fluorescence in situhybridization(FISH) on the prenatal diagnosis of chromosomal abnormalities. Methods: To assay,the prenatal diagnosis of chromosome aneuploidies by FISH analysis of chromosome-specific probes(Chromosome 13,21,18,X,Y) in interphase amniocytes of 1128 pregnant women of 16-22weeks of gestational age,comparing with the assay of with control group which the amniotic cell chromosome karyotyping.Results: All the 1128 cases had been successfully d... |
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| Keywords: | Fluorescence in situ hybridization Pregnatal diagnosis Interphase amniocytes Chromosomal numerical aberration |
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