腮腺放射性损伤的组织病理学观察和高压氧预防作用评价

目的：探讨腮腺放射性损伤的组织病理学改变和高压氧预防腮腺放射损伤的作用。方法：对两组大白兔一侧腮腺区作放射总量为16Gy钴^60放射，其中一组在放射期间和放射结束后作16舱次高压氯(0．25MtPa)吸入，放射结束后42周，光镜下观察放射侧腮腺组织学变化。结果：16例腮腺标本均可见腺体萎缩，小叶中央坏死，间质纤维化，血管管腔狭窄，但小叶边缘浆液性腺泡细胞和间质内导管存在。两组间腮腺损伤的程度无差异。结论：高压氧吸入对预防腮腺损伤无明显作用。在一定的放射剂量范围内，部分腮腺小叶边缘腺泡细胞可避免不可逆性放射性损伤。

Histopathological study on parotid gland damage induced by radiation and evaluation of the prevention effect of hyperbaric oxyegen

Objective:The purpose of this study is to observe the histopathological changes in parotid gland damage induced by radiation and the effect of hyperbaric oxygen(HBO) on preventing the radiation damage of parotid gland. Method:The parotid gland region of two groups of rabbits were radiated by cobatt-60 16 Gy in total does. One group of rabbits intake 16 times of HBO(0.25 Mpa) during and after the radiation. The radiated parotid gland were histopathologically observed by light microscope in 42 weeks after radiation.Result: The parotid gland atrophy, necrosis in the center of parotid gland lobule, interstitial fibrosis and narrowing of blood vessel lumina were observed, and serous acinar cells in the lobule margin and duct in interstitial tissue persisted in 16 specimenes of radiated parotid gland. There was not difference between two groups in degree of the radiated damage.Conclusion: Intake of HBO has not obvious effect of preventing the damage of parotid gland. The part of acinar cells in margin of parotid gland could be avoid irreversible radiation damage in the critical radiation does.