竹节参总皂苷抗炎机制的研究

目的观察竹节参的有效成分竹节参总皂苷（TSPJ）的抗炎作用并探讨其抗炎机理。方法采用小鼠巴豆油耳肿胀实验、冰醋酸致小鼠腹腔毛细血管通透性增高实验及小鼠角叉菜胶足肿胀实验观察TSPJ的抗炎作用，检测小鼠腹膜炎时血清MDA、SOD、GSH—Px值。结果TSPJ（75、150、300mg·kg^-1灌胃能显著抑制巴豆油所致的小鼠耳肿胀、冰醋酸引起的小鼠腹腔毛细血管通透性增强和角叉菜胶所致的小鼠足肿胀，可减少血中MDA的生成，恢复小鼠胸膜炎血清SOD、GSH-Px的活力。结论TSPJ具有明显的抗炎作用，其机制可能与减少炎症部位自由基生成．抑制脂质过氧化反应的生成有关。

Anti-inflammatory Effect of Total Saponins of Panax Japonicus

Objective To observe the anti-inflammatory effect of total saponins of Panax japonicus （TSPJ and its possible mechanism. Methods The anti-inflammatory effect of TSPJ was observed by croton oilinduced mice ear edema test, acetic acid-induced abdominal capillary heperpermeability test and carrageenininduced paw edema test. And The blood plasma GSH-PX, SOD, MDA content was determined . Results TSPJ （75,150,300mg · kg^-1）can inhibit remarkably croton oil-induced ear edema, acetic acid-induced abdominal capillary heperpereability and carrageenin-induced paw edema. TSPJ can enhance activities of GSH-PX,SOD and decrease the concentration of MDA. Conclusion TSPJ exerts a definite anti-inflammatory effect on mice. It maybe TSPJ can strengthen the anti-oxidation, clear up free radicals in mouse body efficiently.