HER2、COX-2在非小细胞肺癌中的表达意义

目的：探讨人表皮生长因子受体2（human epidermal growth factor receptor 2，HER2）和环氧化酶2（cyclooxygenase-2，COX-2）在非小细胞肺癌（non-small cell lung cancer，NSCLC）中的表达，其各自与临床特征之间的关系及二者在NSCLC中表达的相互关系。方法采用免疫组化链霉菌抗生物素蛋白-过氧化物酶（streptavidin-peroxidase，SP）法检测72例NSCLC中HER2、COX-2的表达情况。结果①72例NSCLC中， HER2、COX-2的阳性表达率分别为55.6%、65.3%；②HER2在NSCLC中的阳性表达与组织学类型、分化程度、肿块大小、淋巴结转移及临床分期相关（P＜0.05），而与性别、年龄、吸烟、病变部位无关（P＞0.05）；③COX-2的阳性表达与年龄、组织学类型、肿块大小、淋巴结转移及临床分期相关（P＜0.05），而与性别、吸烟、病变部位及分化程度无关（P＞0.05）；④HER2、COX-2在NSCLC中的阳性表达呈正相关关系。结论 HER2、COX-2可以作为判断NSCLC恶性程度的生物学指标。

Expression of HER2 and COX-2 in non-small cell lung cancer

Objective To investigate the expression of HER2 and COX-2 in non-small cell lung cancer (NSCLC) and the association with patients' clinical characteristics. Method The protein expression of HER2 and COX-2 were detected in 72 NSCLC patients by immunohistochemistry with streptavidin-peroxidase (SP) methods. Result (1) The positive expression rate of HER2 and COX-2 were 55.6% and 65.3%, respectively. (2) The expression of HER2 was significantly correlated with histological type, differentiation, size of mass, lymph node metastasis and clinical stage (P<0.05), while it was not related with patients' sex, age, tumor site and smoking status (P>0.05). (3) COX-2 ex-pression was related to patients' age, histological type, mass size, lymph node metastasis and clinical stage (P<0.05), but no significant correlation was found between COX-2 expression and patients ’sex, smoking status, tumor site and differentiation (P>0.05). (4) There was statistically positive correlation between expression of HER2 and COX-2. Conclusion Detection of HER2 and COX-2 can be used as indicators for prognosis in NSCLC.