| 乌腺金丝桃对抑郁症大鼠海马单胺类神经递质含量5-HT及5-HIAA的影响 |
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| 引用本文： | 李冀,吴全娥,高彦宇,石鑫,唐明哲,曹明明. 乌腺金丝桃对抑郁症大鼠海马单胺类神经递质含量5-HT及5-HIAA的影响[J]. 中医药信息, 2012, 29(5): 18-20 |
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| 作者姓名： | 李冀 吴全娥 高彦宇 石鑫 唐明哲 曹明明 |
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| 作者单位： | 黑龙江中医药大学,黑龙江哈尔滨,150040 |
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| 基金项目： | 国家十一五重大新药创制科技专项（2009ZX09103-302） |
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| 摘 要： | 目的:探讨乌腺金丝桃对抑郁症大鼠海马单胺类神经递质五羟色胺(5-HT)及五羟吲哚乙酸(5-HIAA)含量的影响。方法:建立大鼠孤养结合慢性不可预计性应激抑郁模型,用酶联免疫法测定药物对单胺类神经递质5-HT及5-HIAA含量的影响。结果:乌腺金丝桃高剂量组(2.88g/kg)能显著提高大鼠慢性不可预计性应激抑郁模型的单胺类神经递质5-HT及5-HIAA的含量。结论:乌腺金丝桃具有一定的抗抑郁作用,其抗抑郁作用可能与增加海马单胺类神经递质5-HT及5-HIAA含量有关。
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| 关 键 词： | 乌腺金丝桃 抗抑郁 慢性不可预计性应激抑郁模型 单胺类神经递质 |
The Effect of Hypericum Attenuatum Choisy on the Contents of 5 - HT and 5 -HIAA from Hippocampus Monoamine Neurotransmitters of Depressive Rats |
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| LI Ji , WU Quan-e , GAO Yan-yu , SHI Xin , TANG Ming-zhe , CAO Ming-ming. The Effect of Hypericum Attenuatum Choisy on the Contents of 5 - HT and 5 -HIAA from Hippocampus Monoamine Neurotransmitters of Depressive Rats[J]. Information on Traditional Chinese Medicine, 2012, 29(5): 18-20 |
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| Authors: | LI Ji WU Quan-e GAO Yan-yu SHI Xin TANG Ming-zhe CAO Ming-ming |
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| Affiliation: | LI Ji, WU Quan - e, GAO Yan- yu, SHI Xin, TANG Ming - zhe, CAO Ming - ming ( Heilongiiang University of Chinese Medicine,Harbin 150040, China) |
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| Abstract: | Objective ： To study the effect of hypericum attenuatum Choisy. by surveying cerebral contents （5 - HT and 5 - HIAA） which exist in depressive model. Method ： Establish chronic stress rats model of depression by singly housing and exposing to unpredictable stressors, and detect cerebral contents of monoamine neuro- transmitters （5 - HT and 5 - HIAA） with ELISA. Result ： The high group of Hypericum attenuatum Choisy. （2. 88g/kg） could increase cerebral contents of 5 -HT and 5 -HIAA significantly. Conclusion ：Hypericum at- tenuatum Choisy. plays a role of the antidepression, and the possible mechanism of hypericum attenuatum Choisy. for antidepressant effect may be involved in increasing contents of 5 - HT and 5 - HIAA. |
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| Keywords: | Hypericum attenuatum choisy Antidepression Chronic and unpredictable stress model of depres- sion Monoamine neurotransmitters |
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