Cor pulmonale and silicosis: a necropsy based case-control study. |
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| Authors: | J Murray G Reid D Kielkowski and M de Beer |
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| Institution: | National Centre for Occupational Health, Johannesburg, South Africa. |
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| Abstract: | The presence of cor pulmonale at death in relation to other factors such as emphysema, silicosis, and thromboembolism was analysed in a case-control study of 732 South African gold miners. Marked emphysema was the highest risk factor with an odds ratio of 21.32 (95% confidence interval (95% CI) 5.02-90.7), then extensive silicosis (OR 4.95, 95% CI 2.92-8.38) and thromboembolic disease (OR 1.92, 95% CI 1.37-2.69). Age and smoking were not significant predictors of cor pulmonale. |
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