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| 小柴胡汤对正常大鼠胃肠激素影响的研究 | |
| 引用本文： | 叶勇,石拓,邱明义,牛潞芳. 小柴胡汤对正常大鼠胃肠激素影响的研究[J]. 中国中西医结合消化杂志, 2006, 14(3): 144-146 |
| 作者姓名： | 叶勇 石拓 邱明义 牛潞芳 |
| 作者单位： | 1. 江汉大学医学与生命科学学院,中医系,湖北,武汉,430056 2. 武汉市中西医结合医院,消化内科,湖北,武汉,430014 3. 湖北中医学院,湖北,武汉,430061 4. 北京中医药大学 |
| 摘 要： | [目的]观察小柴胡汤对大鼠血及胃组织胃动素（MOT）、促胃液素（Gas）和血管活性肠肽（VIP）的影响，探讨该方促胃肠动力作用的可能机制。[方法]健康SD大鼠30只随机分为小柴胡汤、莫沙比利和0．85％氯化钠3组，每组10只。用药后采用放射免疫方法检测大鼠血和胃组织中的MOT、Gas及VIP水平。[结果]小柴胡汤组可升高血和胃组织中MOT，与0．85％氯化钠组比较差异有统计学意义（P〈0．05），与莫沙比利组比较差异无统计学意义（P〉0．05）；小柴胡汤对血和胃组织中的Gas和VIP与0．85％氯化钠组比较P〉0．05。[结论]小柴胡汤的促胃肠动力作用可能与MOT密切相关。 |
| 关 键 词： | 小柴胡汤 胃肠激素 胃肠动力 |
| 文章编号： | 1671-038X（2006）03-0144-03 |
| 收稿时间： | 2006-03-30 |
| 修稿时间： | 2006-03-30 |
Effect of Xiaochaihu decoction on gastrointestinal hormone of rats |
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| YE Yong,SHI Tuo,QIU Ming-yi,NIU Lu-fang. Effect of Xiaochaihu decoction on gastrointestinal hormone of rats[J]. Chinese Journal of Integrated Traditional and Western Medicine on Digestion, 2006, 14(3): 144-146 | |
| Authors: | YE Yong SHI Tuo QIU Ming-yi NIU Lu-fang |
| Affiliation: | 1,Department of TCM, School of Medicine and Life Science, Jianghan University, Wuhan 430056, China;2,Wuhan Chinese and Western Medicine Hospital, Wuhan 430014, China;3,Hubei College of TCM, Wuhan 430061, China; 4,Doctor of Grade 2003, Bejing University of Chinese Medicine, Beijing 100029, China |
| Abstract: | [Objective] To observe the effect of Xiaochaihu decoction(XCD) by detecting the content of motilin(MOT) and gastrin(Gas) and vasoactive intestinal polypeptide(VIP) in blood and stomach in rats,and investigate its mechanism.[Methods] The rats were divided into three groups randomly: XCD group,mosapride group and saline group.After the treatment,MOT,Gas and VIP in blood and stomach were detected by the method of radioimmunoassay respectively.[Results] The contents of MOT in blood and stomach in XCD group increased significantly than those in saline group(P<0.05),while there was no significant difference between XCD group and mosapride group(P>0.05).The contents of of Gas and VIP in blood and stomach showed no significant difference between XCD group and saline group(P>0.05).[Conclusion]XCD can increase MOT,which may be the main mechanism of promoting gastric motivity. |
| Keywords: | Xiaochaihu decoction(XCD) gastrointestinal hormone gastrointestinal motivity |
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