C-reactive protein,platelets, and patent ductus arteriosus |
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| Authors: | Leonardo Meinarde Macarena Hillman Alina Rizzotti Ana Lisa Basquiera Aldo Tabares Eduardo Cuestas |
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| Institution: | 1. Department of Pediatrics and Neonatology, Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC), Córdoba, Argentina;2. Hematology and Oncology, Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC), Córdoba, Argentina;3. Vascular Medicine and Thrombosis, Hospital Privado, Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC), Córdoba, Argentina;4. Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Córdoba, Argentina |
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| Abstract: | The association between inflammation, platelets, and patent ductus arteriosus (PDA) has not been studied so far. The purpose of this study was to evaluate whether C-reactive protein (CRP) is related to low platelet count and PDA. This was a retrospective study of 88 infants with a birth weight ≤1500 g and a gestational age ≤30 weeks. Platelet count, CRP, and an echocardiogram were assessed in all infants. The subjects were matched by sex, gestational age, and birth weight. Differences were compared using the χ2, t-test, or Mann–Whitney U-test, as appropriate. Significant variables were entered into a logistic regression model. The association between CRP and platelets was evaluated by correlation and regression analysis. Platelet count (167 000 vs. 213 000 µl?1, p = 0.015) was lower and the CRP (0.45 vs. 0.20 mg/dl, p = 0.002) was higher, and the platelet count correlated inversely with CRP (r = ?0.145, p = 0.049) in the infants with vs. without PDA. Only CRP was independently associated with PDA in a logistic regression model (OR 64.1, 95% confidence interval 1.4–2941, p = 0.033). |
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| Keywords: | C-reactive protein patent ductus arteriosus platelets |
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