Lipid profile,inflammation, and oxidative status in peri- and postmenopausal women |
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| Authors: | Ouarda Taleb-Belkadi Hadjer Chaib Lakhdar Zemour Azzedine Fatah Belkacem Chafi |
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| Affiliation: | 1. Laboratoire de Nutrition Clinique et Métabolique, Département de Biologie, Faculté des Sciences de la Nature et de la Vie, Université d’Oran 1 Ahmed Benbella, Oran, Algérie,;2. Service d’épidémiologie, Etablissement Hospitalier Universitaire Oran, Oran, Algérie,;3. Direction de la santé et de la population d’Oran, Oran, Algérie, and;4. Service de Maternité. Etablissement Hospitalier Universitaire Oran, Oran, Algérie |
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| Abstract: | Objective: To evaluate the effect of perimenopause and postmenopause on lipid profile, inflammation, and oxidative stress in women.Methods: This cross-sectional study included 117 women (47?±?6 years) classified as perimenopausal (n?=?47), postmenopausal (n?=?40), or non-menopausal (n?=?30). In serum, we analyzed lipid profile, tumor necrosis factor-alpha (TNF-α), interleukin-1α (IL-1α), and C-reactive protein (CRP). Pro-oxidant status was assessed by thiobarbituric acid reactive substances (TBARS) and protein carbonyls. Antioxidant defense was performed by analysis of superoxide dismutase (SOD) and catalase activities.Results: Compared to non-menopausal women, triacylglycerols (TG) were similar, total cholesterol and LDL-C were higher in perimenopausal and postmenopausal women, while HDL-C concentrations were decreased. TNF-α and IL-1α were higher in postmenopausal women, while CRP concentrations were elevated in both peri-and postmenopausal women (p?p?p?Conclusion: Menopausal transition and postmenopause were associated with dyslipidemia, inflammation, and unbalanced oxidative status exposing women to cardiovascular risk. |
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| Keywords: | Antioxidant defense inflammation perimenopause postmenopause pro-oxidant |
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