Low level of Nesfatin-1 is associated with gestational diabetes mellitus |
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| Authors: | Ferit Kerim Kucukler Umit Gorkem Yasin Simsek Ramazan Kocabas Sebnem Gulen Serdar Guler |
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| Institution: | 1. Department of Endocrinology,;2. Department of Obstetrics and Gynecology, Faculty of Medicine, Hitit University, Corum, Turkey,;3. Department of Endocrinology, Kayseri Training and Research Hospital, Kayseri, Turkey,;4. Department of Biochemistry, Faculty of Medicine, Hitit University, Corum, Turkey, and;5. Department of Physiology, Faculty of Medicine, Ufuk University, Ankara, Turkey |
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| Abstract: | Introduction: Gestational diabetes mellitus (GDM) occurs in ～10–25% of pregnancies. Nesfatin-1, plays a role in carbohydrate metabolism by inhibiting glucagon secretion, besides has a glucose-dependent insulinotropic effect. Explanation of the GDM pathogenesis is important due to preventing gestational complications. We aimed to investigate relationship between GDM and Nesfatin-1.Material and methods: Seventy-nine pregnant subjects were randomly allocated to either GDM group (GDG, n?=?38) or control group (CG, n?=?41). For GDM diagnosis, 50 and 100?g oral glucose tolerance test (OGTT) were used. Nesfatin-1, insulin and other parameters were measured for all subjects. The homeostasis model assessment-insulin resistance (HOMA-IR) was calculated.Results: Nesfatin-1 was found lower and insulin was found higher in GDG than CG. Negative correlation has been founded between Nesfatin-1 with weight, BMI, fasting glucose, serum glucose level at first hour of the 50?g OGTT and HOMA-IR.Conclusion: In this study, patients with GDM had lower Nesfatin-1 levels than without GDM. Therefore, when the Nesfatin-1 effects on the GDM pathogenesis is clear, it may be contributed to diagnosis and treatment of the GDM. |
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| Keywords: | Gestational diabetes mellitus insulin resistance Nesfatin-1 |
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