Neopterin and hsCRP are not correlated in gestational diabetes mellitus |
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| Authors: | Anara Karaca Tülay Omma Canan Dura Deveci Filiz Bakar Kübra Doğan Yalçın Aral |
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| Affiliation: | 1. Department of Endocrinology and Metabolism and anarkina@gmail.com;3. Department of Endocrinology and Metabolism and;4. Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Altinda?, Ankara, Turkey, and;5. Department of Biochemistry, School of Pharmacy, Ankara University, Tando?an, Ankara, Turkey |
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| Abstract: | Objective: To determine serum neopterin and high sensitive C-reactive protein (hsCRP) levels in patients with and without gestational diabetes mellitus (GDM).Methods: Neopterin and hsCRP levels were quantified in 28 women with GDM and 20 pregnant women with normal glucose tolerance (NGT). Postpartum neopterin and hsCRP levels were measured in a follow-up study.Results: Neopterin levels were significantly higher in women with GDM than in women with NGT (15.89?±?8.19?nmol/L versus 10.4?±?3.8?nmol/L, p?p?p?=?0.9, respectively). In contrast, hsCRP levels decreased after delivery in patients with GDM (5.74?±?3.91 versus 3.78?±?2.78, p?r?=?0.3, p?=?0.02) and fasting glucose (r?=?0.4, p?=?0.004), postprandial glucose (r?=?0.3, p?=?0.01), HbA1c (r?=?0.3, p?=?0.02), whereas hsCRP levels were correlated with pre-pregnancy (r?=?0.3, p?=?0.04) and pregnancy body mass index (r?=?0.4, p?=?0.008). No correlation between serum neopterin and hsCRP levels was found (p?=?0.9).Conclusion: Neopterin levels increased in patients with GDM; hence, it may be related to inflammation. However, the lack of correlation between neopterin and hsCRP suggests the role of different attitudes of these two parameters in the course of pregnancy and GDM. |
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| Keywords: | Gestational diabetes mellitus hsCRP inflammation neopterin pregnancy |
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