利培酮对焦虑抑郁共病的疗效比较

目的观察利培酮联合氟西汀对焦虑抑郁共病的疗效和安全性。方法86例焦虑抑郁共病患者随机分为研究组(利培酮 氟西汀)44例、对照组(氟西汀)42例,治疗8周。于治疗前、治疗后每2周测评汉密尔顿抑郁量表(HAMD)24项、汉密尔顿焦虑量表(HAMA)、治疗中需处理的不良反应量表(TESS)。疗效评价以HAMD减分率为标准,不良反应以TESS评分为标准。结果两组HAMD、HAMA评分组间比较从第2周周末开始差异有显著性(P<0.05、P<0.01),两组疗效比较差异有显著性(P<0.05),各时期TESS评分比较差异无显著性(P>0.05)。结论利培酮联合氟西汀治疗焦虑抑郁共病的疗效和安全性较好。

Comparison of Risperidone in Treatment for Comorbid of Depression and Anxiety

OBJECTIVE To compare the efficacy and side effects of risperidone combined with fluoxetine on patients with comorbid of depression and anxiety.METHODS Eighty-six patients with comorbid of depression and anxiety were randomly divided into study group(risperidone fluoxetine,n=44)and control group(fluoxetine,n=42)and observed for 8 weeks.All patients were assessed with HAMD-24,HAMA and TESS.RESULTS The significant difference in HAMD and HAMA from second weekend between two groups was found but no significant difference in TESS.CONCLUSION Risperidone combined with fluoxetine has better efficacy and safety in treatment for comorbid of depression and anxiety.