A possible autocrine role for interleukin-6 in two lymphoma cell lines |
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| Authors: | Yee C; Biondi A; Wang XH; Iscove NN; de Sousa J; Aarden LA; Wong GG; Clark SC; Messner HA; Minden MD |
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| Institution: | Department of Medicine and Medical Biophysics, Ontario Cancer Institute, Toronto, Canada. |
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| Abstract: | Interleukin-6 (IL-6) is a growth factor with diverse biologic activity. Originally described as a T-cell product that enhances immunoglobulin (Ig) secretion in antigen-stimulated B cells, it also affects the growth of T cells, plasmacytomas, hybridomas, and hematopoietic stem cells. We report the expression and secretion of IL-6 by two lymphoma cell lines, OCI-LY3 and OCI-LY12. Addition of recombinant IL-6 stimulated their growth, whereas addition of polyclonal anti- recombinant IL-6 (anti-rIL-6) had a marked inhibitory effect on proliferation. These results suggest an autocrine role for IL-6 in the growth of these lymphoma cells in culture. |
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