| hPTTG1与肿瘤发生发展的研究进展 |
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| 引用本文： | 高英杰,杨娟,张超,韩竞春.hPTTG1与肿瘤发生发展的研究进展[J].临床肿瘤学杂志,2014,19(5):469-472. |
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| 作者姓名： | 高英杰 杨娟 张超 韩竞春 |
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| 作者单位： | 116021.辽宁大连 大连大学附属新华医院肿瘤科 |
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| 摘 要： | 人垂体瘤转化基因（hPTTG）是一种潜在的癌基因，自发现以来一直是研究的热点，在人体肿瘤中主要表达hPTTG1，且在多种肿瘤中高表达。研究证实，hPTTG1具有促进细胞转化、血管生成及肿瘤转移等生物学功能，在肿瘤的发生、发展、侵袭、转移及复发中起重要作用。hPTTG1对肿瘤的诊断具有重要的参考价值，有望成为肿瘤基因治疗的新靶点。
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| 关 键 词： | 人垂体瘤转化基因1（ hPTTG1） 肿瘤 |
| 收稿时间： | 2013-11-06 |
| 修稿时间： | 2014-02-09 |
The research progress of hPTTG1 in the occurrence and development of tumors |
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| GAO Yingjie,YANG Juan,ZHANG Chao,HAN Jingchun.The research progress of hPTTG1 in the occurrence and development of tumors[J].Chinese Clinical Oncology,2014,19(5):469-472. |
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| Authors: | GAO Yingjie YANG Juan ZHANG Chao HAN Jingchun |
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| Institution: | Department of Oncology， Xinhua Hospital of Dalian University，Dalian 116021，China |
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| Abstract: | As a potential oncogene, human pituitary tumor transforming gene（ hPTTG） has been always the research foucs since it was discovered. hPTTG1 is mainly expressed in human tumors and highly expressed in a variety of tumors. Related studies have shown that hPTTG1 has the function of promoting cell transformation, angiogenesis, tumor metastasis and other biological functions. Be-sides, it plays an important role in tumorigenesis,occurrence,development,invasion, metastasis and recurrence of tumors. hPTTG1 has important reference value for diagnosis of tumor, and it represents potential target for gene therapy of tumor. |
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| Keywords: | Human pituitary tumor transforming gene （hPTTG1） Tumor |
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