麝香保心丸联合异山梨酯治疗不稳定型心绞痛的疗效及安全性分析

目的 探讨麝香保心丸联合异山梨酯治疗不稳定型心绞痛（UAP）的疗效及安全性。方法 选择2014年6月-2016年6月榆阳区中医医院收治的80例UAP患者，随机分为两组，每组给40例，均予以基础治疗方案，对照组在基础治疗方案上加用异山梨酯治疗，治疗组加用麝香保心丸联合异山梨酯治疗，两组均连续治疗2周。比较两组每日心绞痛发作次数、硝酸甘油用量以及心绞痛疗效、心电图（ECG）疗效和药物不良反应。结果 治疗前，两组每日心绞痛发作次数和硝酸甘油用量差异无统计学意义；治疗后，两组每日心绞痛发作次数和硝酸甘油用量均明显减少，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组明显少于对照组，差异有统计学意义（P<0.05）。治疗组心绞痛疗效总有效率为95.0%，明显高于对照组的77.5%，差异有统计学意义（P<0.05）。治疗组ECG疗效总有效率为87.5%，明显高于对照组的65.0%，差异有统计学意义（P<0.05）。治疗组不良反应发生率明显低于对照组，差异有统计学意义（P<0.05）。结论 麝香保心丸联合异山梨酯治疗UAP能显著提升疗效，不良反应少。

Efficacy and safety of Shexiang Baoxin Pill combined with isosorbidedinitrate in the treatment of unstable angina pectoris

Objective To explore the efficacy and safety of Shexiang Baoxin Pill combined with isosorbidedinitrate in the treatment of unstable angina pectoris. Methods 80 cases of UAP patients from Jun.2014 to Jun.2016 were given basic treatment plan, and 40 cases were randomly selected and treated with isosorbidedinitrate as the control group, and the other 40 cases were treated with Shexiang Baoxin Pill combined with isosorbidedinitrate. The incidence of angina pectoris and nitroglycerin dosage, angina pectoris curative effect, electrocardiogram (ECG) curative effect and adverse drug reactions were compared between the two groups. Results Before treatment, daily anginal attacks and nitroglycerin dosage of two groups had no significant difference; after treatment, daily anginal attacks and nitroglycerin dosage between two groups were obviously decreased, the differences of same group before and after treatment was statistically significant (P<0.05); and the treatment group was significantly less than the control group (P<0.05). The total effective rate of angina pectoris in the treatment group was higher than that in the control group, the difference was statistically significant (P<0.05). The total effective rate of ECG in the treatment group was higher than that in the control group, the difference was statistically significant (P<0.05). Conclusions Shexiang Baoxin Pill combined with isosorbidedinitrate in the treatment of UAP can significantly improve the efficacy, and it''s adverse reaction is less.