三维超声评估胎儿心室壁体积的可行性

目的 探讨三维超声时空相关成像（STIC）及虚拟器官计算机辅助分析（VOCAL）技术评估胎儿心室壁体积的可行性。方法 测量247胎22~32⁺⁶周正常胎儿心室壁体积，采用组内相关系数（ICC）分析观察者内及观察者间一致性。测量14胎心脏异常胎儿数据进行有效性验证。结果 胎儿心脏平均室壁体积与孕周具有良好相关性，左心室壁体积=－6.542+0.339×孕周（r²=0.98），右心室壁体积=－7.509+0.384×孕周（r²=0.74）。右心室壁体积（ICC=0.994、0.888）及左心室壁体积（ICC=0.995、0.972）的观察者内及观察者间一致性良好。14胎心脏异常胎儿中，6胎心室壁体积发生改变（小于第5或大于第95百分位数）。结论 STIC及VOCAL技术可用于估测胎儿心室壁体积的参考范围，可重复性良好。

Feasibility of three-dimensional ultrasound in assessment of fetal cardiac ventricular wall volume

Objective To explore the feasibility of spatiotemporal image correlation (STIC) and virtual organ computer-aided analysis (VOCAL) in assessment of fetal cardiac ventricular wall volume. Methods Two hundred and forty-seven normal singleton pregnancies from 22-week to 32⁺⁶ -week were analyzed. The intraclass correlation coefficient (ICC) was used to assess intra-observer and inter-observer concordance. The ventricular wall volume of 14 fetuses with cardiac disorders were evaluated. Results There was good correlation between the mean wall volume and gestational age (GA):The volume of left cardiac ventricular wall=-6.542+0.339×GA (r²=0.98), while the volume of right cardiac ventricular wall=-7.509+0.384×GA (r²=0.74). The intra-observer and inter-observer concordance in assessing the volume of the right (ICC=0.994, 0.888) and left ventricular wall (ICC=0.995, 0.972) were good. The volume of the right and left ventricular wall were altered (<5th percentile and/or >95th percentile) in 6 fetuses of 14 fetuses with cardiac disorders. Conclusion The reference ranges for the volume of the right and left ventricular wall can be calculated with three-dimensional ultrasound using STIC and VOCAL, and the reproducibility is good.