地塞米松联合卡前列素氨丁三醇治疗高危妊娠产妇产后出血的临床疗效

目的 探讨地塞米松联合卡前列素氨丁三醇治疗高危妊娠产妇产后出血的临床疗效及其安全性评价。方法 选取2014年6月-2016年6月在岐山县医院分娩的高危妊娠产妇80例，将其随机分为两组，A组和B组，每组40例，A组产妇接受卡前列素氨丁三醇止血治疗，B组产妇接受地塞米松联合卡前列素氨丁三醇治疗，比较两组产妇产后出血治疗的临床疗效和出血情况，比较分析两组产妇产后出血治疗期间不良反应的发生情况。结果 经治疗，两组患者产后出血的总有效率差异不显著。两组产妇在分娩过程中分别给药0.5 h后，收缩压（SBP）、舒张压（DBP）及心率（HR）较给药前显著升高（P<0.05），但是各指标两组产妇之间比较无显著差异。分娩后2 h内和2~24 h，B组出血量显著较A组少，差异有统计学意义（P<0.05）；两组产妇产后休克指数（Shock index，SI）差异不显著。B组恶心呕吐的发生率显著低于A组，差异有统计学意义（P<0.05），且B组不良反应的总发生例数显著少于A组，差异有统计学意义（P<0.05）。结论 地塞米松联合卡前列素氨丁三醇治疗高危妊娠产妇产后出血的临床疗效显著，可显著控制产妇产后出血量和并降低治疗期间不良反应的发生率，安全性较好，值得临床推广应用。

Curative effect and safety of romethamine combined with dexamethasone on the postpartum hemorrhage for patients with high risk pregnancy

Objective To explore the curative effect and safety of romethamine combined with dexamethasone on the postpartum hemorrhage for patients with high risk pregnancy. Methods 80 patients with high risk pregnancy were enrolled in our hospital from June 2014 to June 2016, of which patients divided into two group randomly, Group A (n=40) accepted romethamine for hemostasis treatment, and Group B (n=40) adopted romethamine combined with dexamethasone treatment. The clinical effect and hemorrhage of patients with postpartum hemorrhage were compared, and the adverse reactions were recorded and analyzed in the period of treatment. Results After treatment, the difference of total effective rate for postpartum hemorrhage from two groups was no significance. After given medicines 0.5 h respectively in delivery process, the SBP, DBP and HR of all parturient women were rising compared with before medicine administration remarkably (P<0.05), but the difference of those between two groups was no significance. Within 24 h after delivery, the hemorrhage of Group B was lower significantly than those patients in Group A (P<0.05). The difference of shock index (SI) from Group A and Group B was no significance. The incidence of nausea and vomiting in Group B was lower than those Group A significantly (P<0.05), and the case of total adverse reactions in group B was fewer significantly than those Group A (P<0.05). Conclusions The romethamine combined with dexamethasone for the postpartum hemorrhage in patients with high risk pregnancy deserved popularization in clinic, of which not only possessed remarkably clinical effect and well safety, but also controlled the postpartum hemorrhage effectively and decreased the incidence of the adverse reactions in the period of treatment.