173例药源性水肿文献分析

目的:探讨药源性水肿的发生规律及特点,为临床安全用药提供依据。方法:对2001～2006年国内医药期刊公开报道的173例药源性水肿文献病例进行统计分析。结果:药源性水肿的发生男性多于女性,但无年龄差别;一般发生时间较短,1h内发生的病例有76例(占43.9%);主要以静脉和口服给药途径为主;涉及药品17类115种,以抗菌药物最多,有54例(占31.2%);水肿类型以喉头水肿为最多,共57例。结论:药源性水肿是一种常见的药品不良反应,必须引起临床医务工作者的重视,尤其对急性喉头水肿,用药后应密切观察,发现问题立即处理。

Drug-induced Edema: Literature Analysis of 173 Cases

OBJECTIVE ： To discuss the general regularity and characteristics of the drug - induced edema so as to provide reference for clinical safe medication. METHODS： 173 drug- induced edema cases publicly reported in domestic journal from 2001 to 2006 were analyzed statistically. RESULTS： The drug- induced edema was more often seen in males than in females, but not linked to age. It was characterized by early onset, with 76 （43.9%） showing edema within lh. It was chiefly induced vial oral and intravenous routes. The drug - induced edema was caused by 17 drug categories （or 115 kinds）, with antibacterials showing the highest percentage （31.2%, 54 cases）. Laryngeal edema, which occurred in 57 cases, was the chief type among all the edema cases. CONCLUSION： Drug- induced edema is a common adverse drug reaction, which should be given great attention in the clinic, much as in the case of acute laryngeal edema. Clinicians should give close monitoring on patients after medication to guard against possible events.