Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia. |
| |
| Authors: | M K Lyons R E Anderson F B Meyer |
| |
| Affiliation: | Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55905. |
| |
| Abstract: | This experiment was designed to determine if intraventricular administration of basic fibroblast growth factor (bFGF) could promote cerebral angiogenesis in a model of mild chronic forebrain ischemia. Wistar rats underwent bilateral carotid artery ligation. Animals received intraventricular injections of bFGF every 4 days for 28 days. Basic fibroblast growth factor caused a significant dose-dependent increase in capillary density compared to ischemic controls in all regions examined. These results support the hypothesis that chronic intraventricular administration of bFGF induces in vivo cerebral angiogenesis. |
| |
| Keywords: | |
|
