| 急性脑梗死患者动脉粥样硬化程度与C反应蛋白的相关性研究 |
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| 引用本文： | 魏亚芬,殷萍,张宇,刘群.急性脑梗死患者动脉粥样硬化程度与C反应蛋白的相关性研究[J].中国急救医学,2008,28(11):1021-1023. |
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| 作者姓名： | 魏亚芬 殷萍 张宇 刘群 |
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| 作者单位： | 1. 吉林大学第一医院神经内科,长春,130021
2. 黑龙江省医院神经内科,哈尔滨,150036 |
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| 摘 要： | 目的 研究急性脑梗死患者血清C反应蛋白(C-reactive protein,CRP)浓度变化与动脉粥样硬化(atherosclerosis,AS)程度、斑块稳定性关系.方法 急性脑梗死患者共416例,经颈动脉彩超确诊的颈动脉内膜厚度(carotid intima-media thickness,IMT)增厚患者284例,非IMT增厚患者132例;284例IMT增厚患者根据颈动脉斑块状态分为管壁增厚组、硬斑块组、混合性斑块组和软斑块组;416例患者根据脑梗死病灶大小分为腔隙性脑梗死组、小面积脑梗死组和大面积脑梗死组.采用免疫散射比浊法测定血清中CRP浓度,统计学分析IMT增厚组与非IMT增厚组、稳定斑块组与不稳定斑块组、不同面积腩梗死组之间CRP浓度的差别.结果 IMT增厚组较非IMT增厚组CRP浓度增高;不稳定性斑块组较稳定性斑块组CRP浓度增高;随着脑梗死面积增加,CRP浓度亦增高,差异有统计学意义(P<0.05).结论 CRP浓度与AS程度、斑块稳定性及脑梗死患者病情密切相关.
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| 关 键 词： | 脑梗死 动脉粥样硬化 动脉斑块 C反应蛋白 |
Correlation between atherosclerosis degree and C-reactive protein in acute brain infarction patients |
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| WEI Ya-fen,YIN Ping,ZHANG Yu,et al..Correlation between atherosclerosis degree and C-reactive protein in acute brain infarction patients[J].Chinese Journal of Critical Care Medicine,2008,28(11):1021-1023. |
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| Authors: | WEI Ya-fen YIN Ping ZHANG Yu |
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| Institution: | WEI Ya-fen,YIN Ping,ZHANG Yu,et al.Neurology Medicine,the First Hospital of Jilin University,Changchun 130021,China |
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| Abstract: | Objective To explore the relationship between atherosclerosis (AS) degree,the stability of carotid artery plaque,the state of illness and serum C-reactive protein(CRP) in acute brain infarction patients.Methods The CRPs of 416 acute brain infarction patients were determined.Doppler ultra-sound was used to measure intima-media thickness(IMT) and the plaque of carotid artery.The patients were divided into several groups according to the IMT,the plaque of carotid artery and the size of infarction.IMT,the plaqu... |
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| Keywords: | Brain infarction Atherosclerosis Plaque of carotid artery C-reactive protein |
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