Vero cell-expressed Epstein-Barr virus (EBV) gp350/220 protects marmosets from EBV challenge |
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| Authors: | E A Emini W A Schleif M Silberklang D Lehman R W Ellis |
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| Affiliation: | Department of Virus, Merck, Sharp and Dohme Research Laboratories West Point, Pennsylvania. |
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| Abstract: | The Epstein-Barr virus (EBV) major membrane antigen, gp350/220, was purified from expressing, genetically engineered Vero cells. The antigen, formulated either with alum or Freund's adjuvant, was inoculated into EBV infection-susceptible marmosets. After several injections, most of the marmosets developed anti-gp350/220 antibodies, and several exhibited virus-neutralizing activity. The immune response elicited by the alum-absorbed antigen proved to be protective upon virus challenge of the inoculated animals. Protection did not correlate with the presence of neutralizing antibodies. |
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| Keywords: | marmoset major membrane antigen vaccine neutralizing antibody |
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