抗环瓜氨酸肽抗体与类风湿因子联合检测在类风湿关节炎中的诊断价值

目的：探讨抗环瓜氨酸肽抗体（抗CCP）与类风湿因子（ RF）联合检测在类风湿关节炎（ RA）中的诊断价值。方法：收集RA患者40例,非RA风湿病患者40例,体检健康人（健康对照组）40名,测定其抗CCP抗体水平和RF值,比较抗CCP抗体和RF对RA诊断的敏感度和特异度。结果：RA组患者血清抗CCP抗体和RF值均显著高于非RA风湿病组和健康对照组（ P〈0.01）。抗CCP抗体,RF单独测定时特异度分别为97.50%和83.75%,灵敏度分别为65.0%和67.5%,2者特异度差异有统计学意义（P〈0.01）,灵敏度差异无统计学意义（P〉0.05）；联合检测抗CCP抗体和RF特异度和灵敏度分别为98.75%和82.50%。结论：抗CCP抗体对RA具有较高的诊断价值,抗CCP抗体和RF联合检测可提高检测的特异度。

Combined detection value of anti-CCP antibody and RF in diagnosis of rheumatoid arthritis

Objective：To investigate the anti-CCP and rheumatoid factor（ RF） in the diagnosis of rheumatoid arthritis（ RA） patients. Methods：Forty cases of patients with RA and 40 cases of patients with other autoimmune diseases and 40 health people（ control group） were selected. The concentration of anti-CCP was determined by electrochemical luminescence analysis and the concentration of RF was determined by chemical analysis,diagnostic sensitivity and specificity of anti-CCP antibodies and RF in RA were compared. Results：The anti-CCP content in the serum of RA patients was found distinctly higher than the control group and non-RA group（P〈0. 01）, control group and non-RA group showed no significant difference with the level of anti-CCP antibody（P〉0. 05）. The sensitivity of anti-CCP antibody and RF was 97. 50% and 83. 75%,there was significant difference between them（P〈0. 01）. The specificity of anti-CCP antibody and RF was 65. 0% and 67. 5%,there was no significant difference between them（P〉0. 05）. The specificity and sensitivity of combined detection of anti-CCP and RF were 98. 75% and 82. 50%. Conclusions：Detection of anti-CCP in Serum has a great value for diagnosis of RA and could be an ideal serological data for diagnosis of RA. Combined detection of anti-CCP antibody and RF could increase the diagnostic specificity and sensitivity.