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Experimental evidence for toxic damage induced by a dimeric anthracenone: diast T-514 (peroxisomicine A2) |
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| Authors: | Francisco Javier Martí nez Rosalba Ramí rez Dur n Noemí Waksman de Torres and Alfredo Pi eyro-L pez |
| Institution: | a Departamento de Farmacología y Toxicologia, Nuevo Léon 66220, México b Unidad de Hígado, Facultad de Medicina, Universdad Autónoma de Nuevo Léon, Apdo, Postal 146, Col. del Valle, Garza Garcia, Nuevo Léon 66220, México |
| Abstract: | Dimeric anthracenones obtained from the genus Karwinskia (Rhamnaceae) are characteristic compounds isolated from the plants of this species. Previous toxicity studies demonstrated Diast T-514 to be toxic to animals in experimental settings. Diast T-514 extracted and characterized from Karwinskia parvifolia, was studied in CD1 mice. The LD50 for this compound was determined. Animals were testedwith Diast T-514 following enteral and parenteral administration. An LD50 dose by both oral and intraperitoneal administration showed selective damage to target organs. |
| Keywords: | Karwinskia Karwinskia parvifolia Dimeric anthracenones Peroxisomicine Diast T-514 Liver toxicity |
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