| INCREASED APOPTOSIS IN LYMPHOMA BONE MARROW ERYTHROID CELLS： POSSIBLE ANEMIC PATHOPHYSIOLOGIC SIGNIFICANCE |
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| 引用本文： | 谷俊侠 陈燕 张纯 刘红利 刘仲萍 郑金娥 姚军霞. INCREASED APOPTOSIS IN LYMPHOMA BONE MARROW ERYTHROID CELLS： POSSIBLE ANEMIC PATHOPHYSIOLOGIC SIGNIFICANCE[J]. 中国癌症研究, 2004, 16(3): 171-175. DOI: 10.1007/s11670-004-0021-y |
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| 作者姓名： | 谷俊侠 陈燕 张纯 刘红利 刘仲萍 郑金娥 姚军霞 |
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| 作者单位： | [1]1DepartmentofHematology [2]HubeiProvinceStemCellResearch＆ApplyingCenter,UnionHospital,TongjiMedicalSchool,HuazhongUniversityofScienceandTechnology,Wuhan430022 |
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| 摘 要： | Objective:To investigate whether excessive erythroid cell apoptosis and/or suppression of proliferation would be implicated in the pathogenesis of anemia associated with lymphoma. Methods: Bone marrow (BM) erythroid cell (CD71^ , GPA^ ) apoptosis(annexin V) and proliferation (Ki-67) were measured by flow cytometry in lymphoma patients and normal donors. Results: BM CD71^ and GPA cells showed a significantly greater proportion of apoptotic cells in lymphoma than in normal samples. Proliferation rate was also significantly increased in lymphoma BM CD71^ and GPA^ cells than in normal samples. Conclusion:Increased apoptosis in lymphoma BM erythroid cells may contribute to the anemia characteristic of this disorder. Proliferation might be up-regulated on BM erythroid cells via negative feedback loop resulting from a state of apoptosis.
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| 关 键 词： | 细胞凋亡 淋巴瘤 肿瘤 骨骼 骨髓 红细胞样细胞 贫血症 |
| 收稿时间： | 2003-05-19 |
| 修稿时间： | 2004-07-22 |
Increased apoptosis in lymphoma bone marrow erythroid cells: Possible anemic pathophysiologic significance |
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| Gu?Jun-xia?Email author,Chen?Yan,Zhang?Chun,Liu?Hong-li,Liu?Zhong-ping,Zheng?jin-e,Yao?Jun-xia. Increased apoptosis in lymphoma bone marrow erythroid cells: Possible anemic pathophysiologic significance[J]. Chinese Journal of Cancer Research, 2004, 16(3): 171-175. DOI: 10.1007/s11670-004-0021-y |
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| Authors: | Gu?Jun-xia? author-information" > author-information__contact u-icon-before" > mailto:junxiagu@yahoo.com.cn" title=" junxiagu@yahoo.com.cn" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Chen?Yan,Zhang?Chun,Liu?Hong-li,Liu?Zhong-ping,Zheng?jin-e,Yao?Jun-xia |
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| Affiliation: | (1) Department of Hematology, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, 430022 Wuhan;(2) Hubei Province Stem Cell Research & Applying Center, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, 430022 Wuhan |
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| Abstract: | Objective: To investigate whether excessive erythroid cell apoptosis and/or suppression of proliferation would be implicated in the pathogenesis of anemia associated with lymphoma. Methods: Bone marrow (BM) erythroid cell (CD71 , GPA ) apoptosis (annexin V) and proliferation (Ki-67) were measured by flow cytometry in lymphoma patients and normal donors. Results: BM CD71 and GPA cells showed a significantly greater proportion of apoptotic cells in lymphoma than in normal samples. Proliferation rate was also significantly increased in lymphoma BM CD71 and GPA cells than in normal samples. Conclusion: Increased apoptosis in lymphoma BM erythroid cells may contribute to the anemia characteristic of this disorder. Proliferation might be up-regulated on BM erythroid cells via negative feedback loop resulting from a state of apoptosis. |
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| Keywords: | Lymphoma Anemia Apoptosis Proliferation |
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