| 基于满秩平行因子分析方法研究左氧氟沙星两种结构型体的荧光光谱及其与酸碱度的关系 |
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| 引用本文： | 郭嘉伟,谢洪平. 基于满秩平行因子分析方法研究左氧氟沙星两种结构型体的荧光光谱及其与酸碱度的关系[J]. 山西医科大学学报, 2010, 41(1): 36-38 |
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| 作者姓名： | 郭嘉伟 谢洪平 |
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| 作者单位： | 1. 第三军医大学药学院药物分析与分析化学教研室,重庆,400038
2. 苏州大学药学院药物分析教研室 |
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| 摘 要： | 目的以满秩平行因子分析方法研究左氧氟沙星两种结构型体的荧光光谱及其与酸碱度的关系。方法测定pH值2．78—7．83范围内左氧氟沙星的三维荧光光谱，并对其三维荧光光谱数据进行满秩平行因子分析。结果测定了左氧氟沙星不同pH值下的三维荧光光谱，得到了其两种不同结构型体（氢键结构型体和双极离子结构型体）的激发光谱、发射光谱和浓度变化曲线。结论获得左氧氟沙星两种不同结构型体的荧光光谱及其在pH值2．78—7．83范围内的浓度变化趋势，为左氧氟沙星的代谢研究提供了更多的基础信息。
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| 关 键 词： | 左氧氟沙星 pH值 三维分辨 荧光光谱 满秩平行因子分析方法 |
The fluorescence spectra of two different structures of levofloxacin and the relationship with pH values by the method of full rank parallel factor analysis |
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| GUO Jia-wei,XIE Hong-ping. The fluorescence spectra of two different structures of levofloxacin and the relationship with pH values by the method of full rank parallel factor analysis[J]. Journal of Shanxi Medical University, 2010, 41(1): 36-38 |
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| Authors: | GUO Jia-wei XIE Hong-ping |
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| Affiliation: | GUO Jia-wei1,XIE Hong-ping2 (1Dept of Pharmaceutical Analysis , Chemical Analysis,College of Pharmacy,The Third Military Medical University,Chongqing 400038,China,2Dept of Pharmaceutical Analysis,College of Pharmaceutical Sciences,Soochow University) |
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| Abstract: | Objective To explore the fluorescence spectra of two different structures of levofloxacin in different pH values by the method of full rank parallel factor analysis. Methods The three dimensional fluorescence spectra of levofloxacin within pH values 2.78-7.83 were determined,and the corresponding data were processed with the method of full rank parallel factor analysis. Results By analyzing the three dimensional spectra of levofloxacin in different pH values,the excitation spectra,emission spectra and conce... |
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| Keywords: | levofloxacin pH value three-way resolution fluorescence spectrum full rank parallel factor analysis |
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