| 非异羟肟酸类肿瘤坏死因子转化酶抑制剂的研究进展 |
| |
| 引用本文： | 孙宇,钟武,李松,贾丽丹. 非异羟肟酸类肿瘤坏死因子转化酶抑制剂的研究进展[J]. 国际药学研究杂志, 2009, 36(3): 172-174 |
| |
| 作者姓名： | 孙宇 钟武 李松 贾丽丹 |
| |
| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850;空军航空大学基础训练基地门诊部,吉林,长春,130021 |
| |
| 摘 要： | 类风湿性关节炎属自身免疫性疾病，全球约有1%～2%的人群受该病困扰。肿瘤坏死因子转化酶(TACE)是治疗类风湿性关节炎的潜在的靶点，当前TACE抑制剂主要分为异羟肟酸类和非异羟肟酸类抑制剂两类。本文对近几年来出现的新型非异羟肟酸类TACE小分子抑制剂进行介绍，使读者对当前高活性、高选择性非异羟肟酸类TACE抑制剂的发展和设计研究现状有个总体的了解。
|
| 关 键 词： | 药物化学 肿瘤坏死因子转换酶抑制剂 非异羟肟酸类 类风湿性关节炎 |
| 收稿时间： | 2009-02-10 |
Non-hydroxamate tumor necrosis factor converting enzyme inhibitors: research advances |
| |
| SUN Yu,ZHONG Wu,LI Song,JIA Li-dan. Non-hydroxamate tumor necrosis factor converting enzyme inhibitors: research advances[J]. Foreign Medical Sciences(Section of Pharmarcy), 2009, 36(3): 172-174 |
| |
| Authors: | SUN Yu ZHONG Wu LI Song JIA Li-dan |
| |
| Affiliation: | SUN Yu1, ZHONG Wu1, LI Song1, JIA Li-dan2 |
| |
| Abstract: | Rheumatoid arthritis (RA) is one of the most common autoimmune inflammatory diseases, affecting approximately 1%～2% of the worldwide adult population. Tumor necrosis factor-converting enzyme (TACE) has been discovered as a potential therapeutic target for the treatment of RA. Currently, there are two main kinds of TACE inhibitors: hydroxamate TACE inhibitors and non-hydroxamate TACE inhibitors. The recent overseas advance in new small molecule non-hydroxamate TACE inhibitors is introduced in this article. This review aims at providing a perspective to readers about the progress in designing more potent and selective non-hydroxamate TACE inhibitors. |
| |
| Keywords: | medicinal chemistry tumor necrosis factor converting enzyme inhibitors non-hydroxamate rheumatoid arthritis |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《国际药学研究杂志》浏览原始摘要信息 |
|
点击此处可从《国际药学研究杂志》下载全文 |
