| 氟对大鼠脑组织中一氧化氮合成酶活性的影响 |
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| 引用本文： | 徐顺清 陈志飞. 氟对大鼠脑组织中一氧化氮合成酶活性的影响[J]. 职业卫生与病伤, 1998, 13(3): 136-138 |
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| 作者姓名： | 徐顺清 陈志飞 |
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| 作者单位： | 同济医科大学环境医学研究所!430030(徐顺清，舒柏华)，武汉市结核病防治所(陈志飞) |
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| 摘 要： | 本文利用化学发光分析技术测定大鼠脑组织中的一氧化氮合成酶的活性，研究氟对神经系统的作用机理。结果表明，无论在体内还是在体外，氟能使一氧化氮合成酶的活性增高，而且这种增强作用能被一氧化氮合成酶的抑制剂L－硝基精氨酸所阻断。
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| 关 键 词： | 氟 一氧化氮合成酶 神经毒性 |
Effects of Fluoride on Activites of Nitric Oxide Synthase from Rat Brain |
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| Xu Shun qing, Shu Baihua, Chen Zhifei. Effects of Fluoride on Activites of Nitric Oxide Synthase from Rat Brain[J]. Journal of Occupational Health and Damage, 1998, 13(3): 136-138 |
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| Authors: | Xu Shun qing Shu Baihua Chen Zhifei |
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| Abstract: | To study the mechanism of neurotoxicity of fluoride,the activites of nitric oxide syn thase from rat brain were determined by chemiluminescent method. The results showed that fluo ride can enhance the activities of nitric oxide synthase from rat brain. The increase of activities ofnitric oxide synthase can be inhibited by N-Nitric-L-Arginine,a inhibitor of nitric oxide synthase. |
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| Keywords: | Fluoride Nitric oxide synthase Neurotoxicity |
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