老年高血压病患者左心室肥厚危险因素分析

目的　旨在探讨老年高血压病患者伴发左心室肥厚的危险因素。方法　15 5例老年男性高血压病患者分为高血压伴左心室肥厚组(45例)和高血压无左心室肥厚组(110例) ,比较两组患者2 4h血压监测各项指标、纤维蛋白原及血脂等浓度,用多元逐步回归分析,探讨左心室肥厚的可能影响因素。结果　两组患者之间年龄、体重指数、体表面积差异无显著性意义;但高血压病程、2 4h平均脉压、平均收缩压及纤维蛋白原差异有显著性意义;2 4h平均脉压升高可能为左心室肥厚的独立危险因素。结论　高血压伴发左心室肥厚是长期血压控制不良、代谢紊乱等多因素作用的结果,其中,脉压增大者更易出现左心室肥厚。

Risk factors related to left ventricular hypertrophy in elderly hypertensive patients

Objective To analyze the risk factors related to left ventricular hypertrophy (LVH) in elderly hypertensive patients.Methods 155 male elderly patients with hypertensive disease were divided into two groups:hypertension with LVH (45) and hypertension without LVH (110). Blood pressure parameters were measured using 24-hour ambulatory blood monitoring.Plasma fibrinogen and lipid were compared between the two groups. The effects of these factors on LVH were analyzed using stepwise multivariate regression analysis.Results There were no significant differences in age, body mass index, and body surface area between the two groups,but 24-hour average pulse pressure, systolic blood pressure, and plasma fibrinogen were significantly different.Rise in 24-hour average pulse pressure was regarded as a significant independent risk factor of LVH.Conclusion Hypertension accompanied by LVH is caused by many factors such as long and under-controlled blood pressure, metabolic disorders etc.,among which rise in pulse pressure may be more apt to be associated with LVH.