高氧水耐缺氧、抗疲劳作用机制初探

目的观察高氧水耐缺氧、抗疲劳的功能，初步研究其作用机制。方法通过对小鼠体质量值、血清尿素氮、肝糖原、乳酸含量、小鼠负重游泳时间、缺氧生存时间、亚硝酸钠中毒存活时间的测定，了解小鼠体能变化情况。结果小鼠运动后血清尿素氮含量降低(P＜0．05)；肝糖原储备量增加(P＜0．05)；常压耐缺氧生存时间、急性脑缺血性缺氧生存时间均延长(P＜0．05)。游泳时间虽无明显差异，但有延长的趋势。结论高氧水能增加能量储备，提高小鼠的应激生存能力，具有耐缺氧、抗疲劳的作用。

Effect of High-oxygen Water on Enhancing Anoxia Endurance and Anti-fatigue Function and the Possible Mechanism

Objective To investigate the effect of high-oxygen water on anoxia endurance and anti-fatigue function in mice and explore the possible mechanism. Methods KM mice were used. Their body weight, serum urea nitrogen, hepatic glycogen, swimming-sustaining time of mice with a load, plasma lactic acid content, survival time under anoxia or sodium nitrite poisoning were measured. Results It was found that high-oxygen water can prolong swimming time and can protract the anoxia survival time of mice under normal pressure and being afflicted with acute cerebral ischemia (P<0.05). It can also decrease the level of serum urea nitrogen after exercise(P<0.05) and increase hepatic glycogen storage(P<0.05). Conclusion The results demonstrate that high-oxygen water can enhance the emergent survival ability of mice, the ability of fatigue recovery and anoxia endurance function. It also can increase the energy storage.