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1 H-MR spectroscopy in ultra-high risk and first episode stages of schizophrenia |
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| Authors: | Uhl Idun Mavrogiorgou Paraskevi Norra Christine Forstreuter Frank Scheel Michael Witthaus Henning Ozgürdal Seza Gudlowski Yehonala Bohner Georg Gallinat Jürgen Klingebiel Randolf Heinz Andreas Juckel Georg |
| Affiliation: | a Dept. of Psychiatry, Ruhr-University Bochum, LWL University Hospital Bochum, Alexandrinenstrasse 1, 44791 Bochum, Germany b Dept. of Psychiatry, Charité, University Medicine Berlin, Germany c Dept. of Neuroradiology, Charité, University Medicine Berlin, Germany |
| Abstract: | Using proton magnetic resonance spectroscopy biochemical characteristics in early stages of schizophrenia were examined. N-acetylaspartate, choline and creatine were measured in hippocampus, anterior cingulate gyrus (ACC) and medial prefrontal cortex (mPFC) of 24 first episode and 30 ultra-high risk patients. Careful LCModel analyses revealed no differences between the patient groups and 31 healthy controls, casting doubt upon the idea of metabolic changes in early stages of psychosis. |
| Keywords: | Magnetic resonance spectroscopy Schizophrenia Ultra-high risk |
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