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Concordance between clinician and patient ratings as predictors of response, remission, and recurrence in major depressive disorder |
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| Authors: | Boadie W. Dunlop Thomas Li Edward S. Friedman Ron Pedersen Martin Keller |
| Affiliation: | a Department of Psychiatry, Emory University School of Medicine, 1256 Briarcliff Road, Building A, 3rd Floor, Atlanta, GA 30306, USA b Global Biostatistics and Programming, Wyeth Research, Collegeville, Pennsylvania, USA c Global Medical Affairs, Wyeth Research, Collegeville, Pennsylvania, USA d Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA e Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA f Department of Psychiatry, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, Massachusetts, USA g Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA h University of Texas Southwestern Medical School, Dallas, Texas, USA |
| Abstract: | We conducted a secondary analysis of data from the Prevention of Recurrent Episodes of Depression With Venlafaxine Extended Release (ER) for Two Years (PREVENT) trial to evaluate whether discrepancies between clinician and patient ratings of depression severity were predictive of response, remission, and recurrence during treatment for a depressive episode. Patients who self-rated depression severity in concordance with the clinician (“concordant patients”) were defined as having a standardized patient-rated Inventory of Depressive Symptoms-Self Report (IDS-SR30) score minus standardized clinician-rated Hamilton Rating Scale for Depression (HAM-D17) score <1 SD from mean. Non-concordant patients (“underrating patients” [−1 SD], “overrating patients” [+1 SD]) were identified. Cohorts were compared for remission and response on the HAM-D17, Clinician Global Impression--Severity (CGI-S), and IDS-SR30 during acute and continuation therapy and time to recurrence during maintenance therapy. During acute treatment female patients were more likely to overrate their depression severity compared to the clinician; older age predicted overrating during continuation treatment. Overrating patients had a slower onset of response on the HAM-D17 during acute treatment (P = 0.004). There were no differences between cohorts for remission or response on the HAM-D17 or CGI-S. Overrating patients at week 10 had lower remission and response rates on the IDS-SR30 during continuation therapy (32% and 50%, respectively; P ≤ 0.001) compared with underrating patients (76%, 77%) or concordant patients (64%, 78%). Patient concordance at the end of continuation therapy did not predict recurrence during maintenance therapy, indicating that patient rating scales may be useful in tracking recurrence during maintenance therapy. Poor agreement between patient- and clinician-ratings of depression severity is primarily a state phenomenon, although it is trait-like for some patients. |
| Keywords: | Depression Psychiatric status rating scales Reliability and validity Outcome assessment Treatment outcome Anxiety |
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