| 益肾活血方治疗兔膝骨性关节炎的实验研究 |
| |
| 引用本文： | 李晓萍,王玉红,李学胜.益肾活血方治疗兔膝骨性关节炎的实验研究[J].中国中医骨伤科杂志,2011(6):7-8. |
| |
| 作者姓名： | 李晓萍 王玉红 李学胜 |
| |
| 作者单位： | 湖北省武警总队医院;湖北省中医药大学濒湖医院; |
| |
| 摘 要： | 目的：观察益肾活血方对家兔膝骨性关节炎模型的疗效及作用机制。方法：将30只新西兰大耳兔随机分成3组,用制动法复制膝骨性关节炎模型。造模1周后,正常组和模型组用生理盐水,药物组用益肾活血方灌胃。于灌胃第6周后,对组织病理学,关节液中IL-1、TNF-α和MMP-3含量的影响进行观察。结果：病理组织学观察药物组软骨破坏减轻,与模型组比较,关节液中IL-1、TNF-α和MMP-3含量明显降低（P〈0.05）。结论：益肾活血方能缓解兔膝骨性关节炎模型关节软骨破坏,并能有效抑制炎症细胞因子（IL-1,TNF-α等）、MMP-3的释放,从而延缓对软骨的降解作用可能是其作用机制。
|
| 关 键 词： | 益肾活血方 膝骨性关节炎 实验研究 |
Experimental Study of Yishenhuoxue Decoction for Treating Knee Osteoarthritis of the Rabbit |
| |
| LI Xiaoping XU Feng GAO Xiaofeng.Experimental Study of Yishenhuoxue Decoction for Treating Knee Osteoarthritis of the Rabbit[J].Chinese Journal of Traditional Medical Traumatology & Orthopeics,2011(6):7-8. |
| |
| Authors: | LI Xiaoping XU Feng GAO Xiaofeng |
| |
| Institution: | LI Xiaoping1 XU Feng1 GAO Xiaofeng1 1Department of Orthopedics,Wuhan Commercial Staff and Worker' Hospital of Hubei Province,Wuhan 430021,China |
| |
| Abstract: | Objective:To study the therapeutic effect and possible mechanisms of Yiqihuoxue decoction on knee osteoarthritis models of rabbit.Methods:Thirty New Zealand rabbits were randomly divided into normal control group,model group,and treatment group.All animals in model group and treatment group were managed by immobilization method.One week later,the rabbits in normal control group and model group were treated with physiological saline,while,the rabbits in treatment group were treated with Yiqihuoxue decoction.... |
| |
| Keywords: | Yiqihuoxue decoction Knee osteoarthritis Experimental study |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
