2012年至2014年北京口岸10万入境人员梅毒血清学检测结果分析

目的：分析2012年至2014年北京口岸全部入境体检人员梅毒特异性抗体的检测结果，为梅毒的防控工作提供参考。方法: 从北京国际旅行卫生保健中心信息系统中获得全部入境体检人员人口学资料与梅毒特异性抗体检测结果，录入至Excel 2016，建立入境体检人员数据库，利用SPSS22.0软件进行统计学分析。结果: 2012年至2014年北京口岸入境体检人员共计106 302人次，按照研究标准有71 308名人员纳入分析，有277人梅毒特异性抗体阳性，阳性率为0.39%(95%CI：0.34%~0.43%)。40~49岁人员阳性率（0.81%）最高，男性阳性率（0.50%）高于女性（0.23%），国籍为非洲的入境人员阳性率（1.27%）高于其他5个地区。多因素Logistic回归分析显示，40~49岁人员梅毒感染危险是＜20岁人员的10.38倍（95%CI：5.59~19.28）；男性人员感染危险是女性的1.85倍（95%CI：1.40~2.44）；国籍为非洲、南美洲、亚洲的入境人员感染危险分别是北美洲入境人员的4.89倍（95%CI：2.97~8.06）、4.82倍（95%CI：2.39~9.74）和1.72倍（95%CI：1.15~2.59），男性和女性阳性率均随年龄增加呈现明显升高趋势（趋势卡方检验，P＜0.05）。除亚洲外，5个地区人员阳性率均随年份略有上升，但趋势不明显（趋势卡方检验，P＞0.05）。在6 246名多次检测的入境人员中检出27名梅毒抗体阳性者，其中9人为研究期间内发生阳转者，累积阳转率为0.14%（9/6 228）,平均阳转时间为（6.3±3.0）个月，不同性别、国籍人员阳转率差异无统计学意义（确切概率法，P＞0.05）。结论： 梅毒防控工作面临严峻挑战，应加强北京口岸入境人员梅毒抗体检测和健康宣教工作，以降低疾病输入和传播的风险，保护易感人群以及促进健康。

Analysis for serological diagnostic results of syphilis among entry personnel in Beijing port during 2012 -2014

Objective:To analyze the results of syphilis specific serological tests among entry personnel in Beijing port during year 201 2 -201 4 in order to provide evidence for the prevention and control of syphilis.Methods:Demographics data and syphilis specific test results of entry personnel were obtained from the information system of Beijing International Travel Healthcare Center and input into Excel 201 6. Database for entry personnel was built up accordingly and was analyzed by IBMSPSS22.0.Results:The number of entry personnel in Beijing port during year 201 2 -201 4 was 1 06 302 person-time.According to the evaluation criteria,71 308 persons were recruited and analyzed,of whom 277 were tested serologi-cally positive and the total prevalence was 0.39% (95% CI:0.34% -0.43%).The prevalence was highest in the persons aged 40 -49 years (0.81 %)and was higher in males (0.50%)than in females (0.23%).The persons from Africa held higher prevalence (1 .27%)than from other five regions.As multivariate logical regression analysis indicated that the risk of syphilis infection was 1 0.38 times more in the persons aged 40 -49 years than in the persons <20 years (95%CI:5.59 -1 9.28),and 1 .85 times more in males than in females (95%CI:1 .40 -2.44).For the people from Africa,South America and Asia,the infection risks were respectively 4.89 times (95%CI:2.97 -8.06),4.82 times (95%CI:2.39 -9.74)and 1 .72 times (95%CI:1 .1 5 -2.59)more than that for the people from North Ameri-ca.Rising trend of the prevalence was observed in both genders by age groups (P value for trend χ2 <0.05).Except for Asia,the prevalences of the people from other five regions were rising slightly by years,however there were no obvious trends (P value for trend χ2 >0.05).Twenty-seven seropositive cases were found within 6 246 entry persons who were tested repeatedly during the research period,9 of which were seroconversion cases so that the cumulative conversion rate was 0.1 4% (9 /6 228).The average conversion time was (6.3 ±3.0)months.There was no statistical significance between the cu-mulative seroconversion rates of the persons with different genders and nationalities (P of Fisher’s exact test >0.05).Conclusion:Serological detection of syphilis for entry personnel in Beijing port and syphi-lis-related health education should be reinforced to reduce the risk of disease importing and spreading, protect susceptible subjects and promote health.