| 氟对大鼠NK细胞和IL－2的影响以及硼对氟的拮抗作用 |
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| 引用本文： | 徐增光,陈荣安,章孟本.氟对大鼠NK细胞和IL－2的影响以及硼对氟的拮抗作用[J].郧阳医学院学报,1994(1). |
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| 作者姓名： | 徐增光 陈荣安 章孟本 |
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| 作者单位： | 同济医科大学郧阳医学院卫生学教研室，同济医科大学劳动卫生与职业病教研室 |
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| 摘 要： | 本文研究了氟对大鼠自然杀伤（ＮＫ）细胞和白细胞介素－２（ＩＬ－２）的影响以及硼对氟的拮抗作用。大鼠饮用加氟水（１１０ｍｇＦ－／Ｌ）和氟硼混和水（１１０ｍｇＦ－＋４４ｍｇＢ３＋／Ｌ）４个月，以饮用自来水为对照。研究结果表明，氟可抑制大鼠脾脏ＮＫ细胞和ＩＬ－２的活性。硼可拮抗氟引起的ＮＫ细胞和ＩＬ－２活性的降低，并使尿氟排出增加，骨氟含量下降。提示氟可抑制非特异性和特异性免疫，硼可拮抗氟的毒性。
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| 关 键 词： | 氟硼，拮抗作用，自然杀伤细胞，白细胞介素－2 |
Effect of Fluoride on the Active of NK Cell and IL-2 and Antagonism of Boron to Fluoride in Rat. |
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| Xu Zhenguang,et al.Effect of Fluoride on the Active of NK Cell and IL-2 and Antagonism of Boron to Fluoride in Rat.[J].Journal of Yunyang Medical College,1994(1). |
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| Authors: | Xu Zhenguang |
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| Abstract: | The study was performed to explore the effect of fluoride on the activity of natural killer(NK)cells and interleukin-2(LL-2) in the rat's spleen,and the antagonism of boron to fluoride.The rats were administered NaF(112mg F-/L)and NaF Borax(11mg F- 4mg B2 /L)in drinking water for momonths;the control was given stilled water.The results showed that fluoride could reduce obviously the activity of NK cells and IL-2,and that boron could advance the decreased actyvity of NK cells and IL-2 caused by fluoride,increase the excretion of fluoride in urine,and decline the content of fluoride in bone.zthe study suggested that fluoride inhibit the non-specific and specific immune fumctions,and boron antagonize the toxicity of fluoride. |
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| Keywords: | fluoride boron antagonism natural-killer-cell interleukin-2 |
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