| 注射用头孢米诺钠与更昔洛韦的配伍稳定性考察 |
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| 引用本文： | 郑厚林,陈阳建.注射用头孢米诺钠与更昔洛韦的配伍稳定性考察[J].中国药业,2010,19(19):3-4. |
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| 作者姓名： | 郑厚林 陈阳建 |
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| 作者单位： | 1. 浙江省宁波市医疗中心李惠利医院,浙江,宁波,315040
2. 浙江医药高等专科学校,浙江,宁波,315100 |
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| 摘 要： | 目的考察注射用头孢米诺钠与更昔洛韦在0.9%氯化钠注射液中的配伍稳定性。方法分别于25℃和37℃条件下采用紫外分光光度法测定配伍液中头孢米诺钠与更昔洛韦的含量变化,同时观察配伍液的外观、pH、微粒变化及紫外吸收光谱的变化。结果配伍液在8 h内外观、pH、主药含量及紫外吸收光谱均无显著变化。结论注射用头孢米诺钠与更昔洛韦在0.9%氯化钠注射液中稳定性良好,可配伍使用。
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| 关 键 词： | 头孢米诺钠 更昔洛韦 配伍稳定性 |
Investigation on Compatible Stability of Cefminox for Injection and Ganciclovir for Injection |
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| Zheng Houlin,Chen Yangjian.Investigation on Compatible Stability of Cefminox for Injection and Ganciclovir for Injection[J].China Pharmaceuticals,2010,19(19):3-4. |
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| Authors: | Zheng Houlin Chen Yangjian |
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| Institution: | 1.Li Huili Hospital,Ningbo Medical Center,Ningbo,Zhejiang,China 315040;2.Zhejiang Pharmaceutical College,Ningbo,Zhejiang,China 315100) |
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| Abstract: | Objective To investigate the compatible stability of Cefminox for Injection and Ganciclovir for Injection in 0.9% sodium chlo-ride injection.Methods The content changes of cefminox and ganciclovir were determined simultaneously and respectively under the condi-tion of 25 ℃ and 37 ℃ by UV-chromatography,and the appearance of the mixed solution was observed,pH and changes of UV spectra were detected.Results There were no evident variations in their contents and pH during 8 h after combination and there was no obvious change in the UV spectra during 8 h when the mixture was laid aside at 25 ℃ and 37 ℃.Conclusion The mixture of cefminox and ganciclovir is stable in 0.9% sodium chloride injection within 8 h,and they can be used in combination when necessary. |
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| Keywords: | cefminox sodium ganciclovir compatible stability |
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