Levetiracetam in stiff-person syndrome |
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Authors: | GianPietro Sechi Marianna Barrocu Maria G Piluzza Giovanni A Cocco Giovanni A Deiana Gian Franco Sau |
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Institution: | (1) Dept. of Neurosciences, University of Sassari, viale S. Pietro, 10, 07100 Sassari, Italy |
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Abstract: | Abstract
We studied the effects of oral levetiracetam (LEV) (500 mg twice daily) in three women with stiff-person syndrome in a single-blind,
placebo-controlled study. The severity of muscle rigidity and of paroxysmal symptoms was assessed by EMG and clinically by
a rating scale of 0–4 and by the Patients Global Impressions Scale. LEV was well tolerated. On active treatment all patients
improved as assessed by any of the objective or subjective outcome measures. No response was noticed on placebo. Our data
indicate that in patients with SPS, LEV is well tolerated and has a therapeutic role in the management of both muscle stiffness
and life-threatening paroxysmal respiratory spasms. |
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Keywords: | " target="_blank"> stiff-person syndrome levetiracetam clinical trial |
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