| 阿司匹林粒径对羟丙甲基纤维素水凝胶骨架片释放度的影响 |
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| 引用本文： | 杨宇欣,陈振阳,周建平.阿司匹林粒径对羟丙甲基纤维素水凝胶骨架片释放度的影响[J].中国药科大学学报,2001,32(2):26-28. |
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| 作者姓名： | 杨宇欣 陈振阳 周建平 |
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| 作者单位： | 中国药科大学药剂学教研室,南京,210009 |
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| 摘 要： | 目的 考察粒径对羟丙甲基纤维素（HPMC）水凝胶骨架片释药行为的影响。方法 以阿司匹林为模型药物，测定不同粒径药物制备的HPMC水凝胶片的释放行为。结果 当HPMC含量较低时，药物粒径愈小，释药速度愈快；当HPMC含量较高时，释药速度在0－4h随粒径的增加而变慢，4－12h后则表现为随粒径的增加释放加快。结论 在某些条件下，增大药物粒径会使释放变快。
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| 关 键 词： | 阿司匹林 粒径 羟丙甲基纤维素 水凝胶骨架片 释放度 |
| 文章编号： | 1000-5048(2001)02-0106-08 |
| 修稿时间： | 2000年11月18 |
Effect of Different Diameter of Aspirin Particles on the Release Behavior of HPMC Hydrogel Matrix Tablets |
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| YANG Yu-Xin,CHEN Zhen-Yang,ZHOU Jian-Ping.Effect of Different Diameter of Aspirin Particles on the Release Behavior of HPMC Hydrogel Matrix Tablets[J].Journal of China Pharmaceutical University,2001,32(2):26-28. |
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| Authors: | YANG Yu-Xin CHEN Zhen-Yang ZHOU Jian-Ping |
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| Institution: | YANG Yu-Xin,CHEN Zhen-Yang,ZHOU Jian-Ping Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | AIM The effect of drug particles on the release behavior of hydrogel matrix tablet of HPMC was studied. METHODS The release behavior of aspirin with different particles was tested. RESULTS When the tablets was made mainly with HPMC and without MCC, the release rate was lower with the decrease of drug diameter in the first 4 h, while from 4 to 24 h the release rate was higher with the decrease of drug diameter. CONCLUSION The release mechanism of HPMC tablets changed when MCC was excluded.= |
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| Keywords: | Diameter of aspirin particle Hydrogel matrix tablets HPMC Release mechanism |
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