地尔硫缓释胶囊联合氯沙坦治疗慢性肾功能不全并发高血压的疗效

目的观察地尔硫缓释胶囊联合氯沙坦治疗慢性肾功能不全并发高血压患者的临床疗效。方法将84例慢性肾功能不全并发高血压患者按随机数字表法分为2组。治疗组43例,采用地尔硫90 mg.次-1,2次.d-1;加氯沙坦50 mg,1次.d-1。对照组41例,给予氯沙坦50 mg,1次.d-1。2组均治疗观察6个月,对2组高血压、心率及血清肌酐水平变化进行比较。结果 2组治疗后的血压均较治疗前明显降低(均P<0.05)。治疗组治疗后心率及血清肌酐水平较治疗前明显下降(均P<0.05),对照组治疗前后心率及血清肌酐水平比较差异均无统计学意义(均P>0.05)。治疗组治疗高血压总有效率为93.02%,对照组总有效率为73.17%,2组比较差异有统计学意义(P<0.05)。结论地尔硫缓释胶囊联合氯沙坦治疗慢性肾功能不全并高血压较单用氯沙坦能更显著地降低患者的血压,且无明显的不良反应,有效地延缓患者的血清肌酐水平的升高。

Efficacy of Diltiazem Sustained-release Capsules Combined with Losartan on Chronic Renal Insufficiency and Hypertension

Objective To observe the efficacy of diltiazem sustained-release capsules combined with losartan in patients with chronic renal failure and hypertension.Methods Eighty-four patients with chronic renal failure and hypertensive were randomly treated with losartan 50 mg once daily alone（control group,n=41）or in combination with diltiazem 90 mg twice daily（treatment group,n=43）for 6 months.The changes in blood pressure,heart rate and serum creatinine level were compared between the two groups.Results After treatment,blood pressure significantly decreased in both groups（P0.05）.In addition,heart rate and serum creatinine level obviously reduced in treatment group（P0.05）,but did not significantly change in control group（P0.05）.The total effective rate in treatment group was significantly higher than that in control group（93.02% vs 73.17%,P0.05）.Conclusion The combined treatment with diltiazem sustained-release capsules and losartan can lower blood pressure and delay the increase in serum creatinine with no adverse reactions in patients with chronic renal failure and hypertension.