血清甘胆酸水平在慢性肝病患者中的临床分析

目的探讨血清甘胆酸检测在慢性肝病患者诊断中的临床意义。方法将135例慢性肝病患者按病情程度分成慢性肝炎轻度组(32例)、中度组(18例)、重度组(8例),肝硬化组(62例),肝癌组(15例),同时选取20名健康体检者作为对照组。用放射免疫法检测各组对象血清甘胆酸的含量。结果慢性肝炎各组及肝硬化、肝癌组血清甘胆酸均高于对照组(P<0.01),血清甘胆酸水平在慢性肝炎各组患者之间差异有统计学意义(P<0.05)。结论慢性肝炎、肝硬化、肝癌患者血清甘胆酸较正常人升高,慢性肝炎患者随着病情加重血清甘胆酸升高。

Serum Cholyglycine Levels in Patients with Chronic Liver Disease

Objective To investigate the clinical significance of detection of serum cholyglycine levels in the diagnosis of chronic liver disease. Methods According to the disease degree, 135 pa- tients with chronic liver disease were divided into mild chronic hepatitis group （32 cases）, moderate chronic hepatitis group （18 cases）, severe chronic hepatitis group （8 cases）, hepatic cirrhosis group （62 cases）and liver cancer group（15 cases）. At the same time selection of 20 healthy persons as control group.Serum cholyglycine levels were measured by RIA. Results Compared with controls, the levels of serum cholyglycine significantly increased in patients with chronic hepatitis, hepatic cirrhosis or liver cancer（P〈0.01 ）. Moreover, there were obvious differences in serum cholyglycine levels among mild chronic hepatitis group, moderate chronic hepatitis group and severe chronic hepatitis group（P〈0.05）. Conclusion The levels of serum cholyglycine in patients with chronic hepatitis, hepatic cirrhosis or liver cancer are higher than those in normal subjects, and serum eholyglycine levels increase during ex- acerbations of chronic hepatitis.