潘托拉唑治疗经皮冠状动脉支架植入术后上消化道出血患者的疗效

目的探讨潘托拉唑对经皮冠状动脉支架植入后上消化道出血的疗效。方法将60例经皮冠状动脉支架植入(PCI)术后上消化道出血的患者按随机数字表法分为潘托拉唑组(30例)和奥美拉唑组(30例)。2组分别采用潘托拉唑或奥美拉唑40 mg加入5%葡萄糖注射液250 mL静脉滴注(30～60 min滴完),2次.d-1,5 d 1个疗程。对2组患者的止血疗效及不良反应进行比较。结果治疗后潘托拉唑组止血显效率为83.3%,总有效率为96.7%;奥美拉唑组止血显效率为70.0%,总有效率为80.0%,2组比较差异均无统计学意义(均P>0.05)。不良反应发生率潘托拉唑组为3.3%,奥美拉唑组为3.3%,2组比较差异无统计学意义(P>0.05)。结论潘托拉唑是治疗PCI术后上消化道出血安全、有效的药物。

Effects of Pantoprazole on Upper Gastrointestinal Bleeding after Percutaneous Coronary Intervention

Objective To evaluate the effects of pantoprazole on upper gastrointestinal bleeding after percutaneous coronary intervention（PCI）.Methods Sixty patients with upper gastrointestinal bleeding after PCI were randomly divided into two groups,with 30 patients in each group.Pantoprazole group and omeprazole group were given intravenous drip infusion of pantoprazole and omeprazole 40 mg in 250 mL of 5% glucose injection twice daily,respectively.The treatment course was 5 days.Hemostatic efficacy and adverse reactions were compared between the two groups.Results There were no significant differences in obvious effective rate,total effective rate and incidence of adverse reactions between the two groups（83.3%,96.7% and 3.3% vs 70.0%,80.0% and 3.3%,respectively;P0.05）.Conclusion Pantoprazole is an effective and safe drug for upper gastrointestinal bleeding after PCI.