| 干扰素抗性株人类乳头瘤病毒的型别分析 |
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| 引用本文： | 罗光浦,;余卓文,;危建安,;谢汉平,;陈国雄.干扰素抗性株人类乳头瘤病毒的型别分析[J].中国性病艾滋病防治,2009(4):405-406. |
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| 作者姓名： | 罗光浦 ;余卓文 ;危建安 ;谢汉平 ;陈国雄 |
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| 作者单位： | [1]佛山市顺德区慢性病防治中心,广东佛山528300; [2]佛山市顺德区疾病预防控制中心,广东佛山528300; [3]广东省中医院,广州510120 |
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| 基金项目： | 广东省社会发展领域科技计划项目（63118） |
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| 摘 要： | 目的检测并分析干扰素抗性株人类乳头瘤病毒的型别。方法于尖锐湿疣局部注射干扰素，在治疗前应用导流杂交技术，对所有的疣体检测人类乳头瘤病毒的型别，并分别对干扰素治疗敏感及抵抗的乳头瘤病毒型别进行统计分析。结果人类乳头瘤病毒6型的治疗抵抗率为9．6％，人类乳头瘤病毒11型的治疗抵抗率却高达31．8％，经统计学分析，差异有统计学意义（Х^2=11．2792，P〈0．05）。结论人类乳头瘤病毒11型较6型更易出现干扰素治疗抵抗。
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| 关 键 词： | 干扰素 乳头瘤病毒 抗药性 |
Analysis of subtypes of HPV with resistance to interferon |
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| Institution: | LUO Guang-pu , YU Zhuo-wen , WEI Yian an, et al. ( Shunde District Center for Prevention and Management of Chronic Diseases, Foshan,Guangdong 528300, China) |
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| Abstract: | Objective To clarify the distribution of subtypes of HPV with resistance to interferon. Methods All subtypes of HPV were determined by flow-through hybridization technique before treatment by local injection to interferon. The distribution of subtypes resistant or sensitive to interferon was statistically analyzed. Results Of the subtype 6 of HPV 9.6% was resistant to interferon treatment,while 31.8% of the subtype 11 of HPV was resistant to interferon. The difference in the response of the two subtypes to treatment was statistically significant （Х^2 = 11. 2792 P〈0. 05）. Conclusions In comparison with subtype 6 of HPV,subtype 11 shows higher resistance to interferon treatment. |
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| Keywords: | Interferon Human papilloma virus Drug resistance |
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