女性静脉注射吸毒感染HIV危险因素的病例对照研究

目的探讨女性静脉注射吸毒（IDus）感染艾滋病病毒（HIv）的危险因素，为制定针对这一人群的干预措施提供理论依据。方法通过1：1配对50对女性IDUs病例对照研究，探索其感染HIV的危险因素。结果对各个变量进行单因素条件Logistic回归分析后发现，与HIV感染有显著相关的因素有：无固定居所、共用针具史、过去1年有多性伴或以性换钱／毒品、有HIV阳性固定性伴、有IDU性伴、有暴力虐待史、曾感染梅毒、认为自己有很大／一定感染HIV危险。HIV感染的危险因素为：有HIV阳性的固定性伴（OR=28．05；95％CI=2．34，335．67），过去一年曾以性换钱鹰品（OR=5．89；95％CI=1．12，31．09），以及无固定居所（OR=10．77；95％CI=1．21，96．06）。结论广东省的女性IDUs中，性行为较注射行为对于HIV传播更为危险，干预重点应该放在如何减少在吸毒情况下经性途径传播HIV的危险因素上。

Case-control study on risk factors to HIV infection among female IDUs in Guangdong province

Objective To explore risk factors to HIV infection among female drug users in Guangdong province in order to develop appropriate gender-specific HIV intervention strategies among them. Method Risk factors to HIV infection were explored in a 1 ： 1 matched case-control study with conditional logistic regression model. Results The results of uni- variate logistic regression indicated that the following factors were significantly associated with HIV infection. They were： absence of permanent residence, a history of sharing needles, having multiple sex partners or exchanging sex for money or drugs in the past year, having a regular HIV positive sex partner, having an IDU sex partner, a history of sex violence or abuse,previous infection with syphilis and being conscious of high risk to HIV infection. The results of conditional multi- variate regression of logistic model showed that risk factors to HIV infection were：having a regular HIV positive sex part- ner（OR = 28.05 ; 95 % CI = 2.34,335.67）, exchanging sex for money/drugs in the past year （ OR = 5.89 ; 95 % CI = 1.12,31.09） ,absence of permanent residence （OR= 10.77;95%CI= 1.21,96.06） .Conclusion Sexual behaviors were more risky for HIV infection than drug use among female IDUs in Guangdong province. Future preventive intervention tai- lored to female IDUs should focus on the reduction of risks of heterosexual transmission in the context of drug using.