胃癌组织中Fas抗原表达与细胞凋亡的关系

目的　研究胃癌组织中Fas抗原表达与细胞凋亡的关系。方法　采用免疫组织化学及脱氧核糖核酸末端转移酶介导的缺口末端标记 (TUNEL)技术对 40例胃癌组织中Fas抗原表达与细胞凋亡进行了观察和比较。结果　胃癌组织中Fas抗原表达阳性率为 5 2 .5 % ,Fas表达阳性的胃癌细胞凋亡指数显著高于Fas抗原阴性组 (t =3 .3 5 ,P <0 .0 1)。结论　胃癌细胞调亡与Fas抗原表达密切相关 ,细胞凋亡调控的异常在胃癌发病中可能起重要作用

Relationship between Fas Antigen Expression and Apoptosis in Human Gastric Carcinoma Tissues

Objective To determine relationship between the expression of Fas antigen and apoptosis in human gastric carcinoma tissues.Method Using immunohistochemical staining and terminal deoxynucleotidyl transferase mediated dUTP nick end labeling(TUNEL) technique,we observed the apoptotic cells and Fas antigen expression in 40 cases of gastric carcinoma tissues.Results The positive rate of Fas antigen expression in gastric carcinoma tissues was 52.5%.The apoptotic index in Fas positive tissues was significantly higher than that in Fas negative tissues( t=3.35,P <0.01).Conclusions The result suggested that cellular apoptosis was closely related to the Fas antigen expression in gastric carcinoma tissues,the abnormal regulation of apoptosis may play an important role in the pathogenesis of gastric carcinoma.