深低温冷藏异体骨治疗骨肿瘤术后骨缺损

目的：探讨深低温冷藏异体骨在骨肿瘤术后骨缺损中的应用价值。方法：对58例骨肿瘤术后骨缺损患植入深低温冷藏异体骨，术后随访观察机体对异体骨的免疫反应，植入骨愈合情况，有无并发症。结果：58例均获得随访，其中，带关节软骨面的大块异体骨移植平均随访22．5个月，除1例外，其余未出现排异反应和感染。骨粒移植，平均随访21．5个月，全部骨性愈合，无一例出现排异反应及感染。结论：深低温冷藏异体骨可以降低机体对异体骨的免疫反应，并可以获得与患的形态和大小相匹配的缺损骨组织，而且保留一定程度的关节功能，它不仅作为生物力学的支持结构，而且还同时具有诱导骨生成的作用。当异体骨移入宿主后，能逐步被血管化，进而爬行替代，一旦移植成功，它将成为永久植入物，并且有自身的塑形、再生和修复功能，这一点是除自体骨以外的所有替代物不能比拟的。

Deep - frozen bone allograft in the treatment of bone tumor

Objective To study the practical value of deep - frozen bone allograft in the treatment of bone defect after resection of bone tumor. Methods fifty - eight patients with bone tumor underwent tumor resection. The bone defects after resection were replaced with deep - frozen bone allograft. The rejection reaction of bone allograft, bone healing and complication were observed during follow- up. Results All 58 patients were followed up. The mean follow - up time of the patients whose defects replaced with massive allograft with joint cartilage was 22.5 months. Bone healing was observed in all except one patient, infection and rejection reaction were not occurred. The mean follow - up time of the patients whose defects replaced with paniculate bone allograft was 21.5 months. Bone union was seen in all patients ; immunoreaction and infection were not observed. Conclusions Deep - frozen storage can minimize the immuno-reaction of bone allograft. The allograft could be made to fit the bone defect in shape and preserve some joint function. This kind of allograft not only is a structural allograft in biomechanics but also has a feature of osteoinductivity.