化学交联剂对树脂牙本质粘接稳定性的影响

随着粘接剂的发展口腔粘接修复在临床得到广泛应用。但牙本质粘接耐久性的问题仍然不容乐观。由于口腔各种酶、细菌等多种因素会导致粘接界面胶原纤维暴露,而裸露的胶原纤维极易降解和疲劳破坏,从而影响牙本质粘接稳定性。基质金属蛋白酶介导的对胶原纤维的降解是粘接界面破坏的主要因素。抑制基质金属蛋白酶活性、增强胶原性能是延长粘接寿命的关键。为此,针对口腔牙本质粘接难点的问题,基于牙本质生物改性的概念,通过使用胶原交联剂的生物活性介导的仿生方法,改变牙本质生物理化性能来强化牙本质胶原纤维强度,增加粘接稳定性。本文主要介绍牙本质生物改性及其相关的基质成分,并对化学胶原交联剂碳化二亚胺及戊二醛进行了综述。

Effect of Chemical Crosslinking Agent on Adhesive Stability of Resin-dentin Bonding

Oral adhesion repair has been widely used with the development of adhesives.But the problem of dentin adhesion durability is not optimistic.Various enzymes,bacteria,and other factors in the oral cavity may lead to the exposure of collagen fibers at the bonding interface,and the exposed collagen fibers are easily degraded and damaged by fatigue,thus affecting the stability of dentin bonding.Matrix metalloproteinase-mediated degradation of collagen fibers is the main factor of adhesion interface damage.Inhibition of matrix metalloproteinase activity and enhancement of collagen properties are the keys to prolong the bonding life.Therefore,in view of the difficulties in the adhesion of oral dentin,based on the concept of biological modification of dentin,the bionic method mediated by the biological activity of collagen cross-linking agent was used to change the biological and physical properties of dentin to strengthen the strength of dentin collagen fiber and increase the adhesion stability.In this paper,the role of crosslinkers in the biological modification of dentin was introduced.