| 间充质干细胞来源的脱细胞基质及其研究进展 |
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| 引用本文： | 冯煜婷,姜治伟,杨国利,谢志坚. 间充质干细胞来源的脱细胞基质及其研究进展[J]. 口腔医学, 2020, 40(3): 271-274,280 |
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| 作者姓名： | 冯煜婷 姜治伟 杨国利 谢志坚 |
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| 作者单位： | 浙江大学医学院附属口腔医院种植科,浙江杭州 310006;浙江省口腔生物医学研究重点实验室,浙江杭州 310006;浙江省口腔生物医学研究重点实验室,浙江杭州 310006;浙江大学医学院附属口腔医院颌面外科,浙江杭州 310006 |
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| 基金项目： | 浙江省卫生厅科技项目;国家自然科学基金 |
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| 摘 要： | 干细胞一直是国内外医学研究的热点,尤其在再生医学领域。间充质干细胞作为应用较广泛的干细胞,通过近年来的研究,其分泌的细胞外基质已经可以被有效获取,它对细胞的增殖、生长以及定向分化有相应的促进作用,具有供体来源丰富、可防止病原传染、减少自身免疫反应等优势,是组织工程学研究的理想生物材料。本文就间充质干细胞来源的脱细胞基质的概念、成分、获取方法、研究进展及应用前景作一综述。
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| 关 键 词： | 间充质干细胞 细胞外基质 组织工程 骨再生 |
Mesenchymal stem cell derived extracellular matrix and its research progress |
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| FENG Yuting,JIANG Zhiwei,YANG Guoli,XIE Zhijian. Mesenchymal stem cell derived extracellular matrix and its research progress[J]. Stomatology, 2020, 40(3): 271-274,280 |
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| Authors: | FENG Yuting JIANG Zhiwei YANG Guoli XIE Zhijian |
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| Affiliation: | (Department of Implantology,Stomatology Hospital,School of Medical,Zhe-jiang University,Hangzhou 310006,China) |
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| Abstract: | Stem cells have been a hotspot of medical research at home and abroad,especially in the field of regenerative medicine.As one of the most widely used stem cells,mesenchymal stem cell derived extracellular matrix(MSC-ECM)has been successfully isolated and proved to be effective in cell proliferation,development and orientated differentiation and so on through recent research.Furthermore,because of its rich resources,preventing pathogen transmission and reducing autoimmunity,MSC-ECM is considered to be an ideal biological material for tissue engineering.This comprehensive review mainly focused on concept,ingredient,the acquisition methods,research progress and application prospect of mesenchymal stem cell-derived extracellular matrix. |
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| Keywords: | mesenchymal stem cell extracellular matrix tissue engineering bone regeneration |
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